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ELISA Kit for Pig Serine-protein kinase ATM

SKU : BHE13801111

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EIAAB SCIENCE INC, WUHAN

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Mfr.No.	E1361p
Alternative Names	Ataxia telangiectasia mutated homolog ; A-T mutated homolog
Categories	Elisa
Function	Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as a tumor suppressor. Necessary for activation of ABL1 and SAPK. Phosphorylates p53/TP53, FANCD2, NFKBIA, BRCA1, CTIP, nibrin (NBN), TERF1, RAD9 and DCLRE1C. May play a role in vesicle and/or protein transport. Could play a role in T-cell development, gonad and neurological function. Binds DNA ends. Plays a role in replication-dependent histone mRNA degradation.
Specificity	Natural and recombinant Pig Serine-protein kinase ATM
Subcellular Location	Nucleus Cytoplasmic vesicle Primarily nuclear. Found also in endocytic vesicles in association with beta-adaptin.
Entryname	ATM_PIG
Platform	PF02259
Protein Name	Serine-protein kinase ATM
Sequence	50: MSLALNDLLI ; CCRQLEHDRA ; TERRKAVENF ; RHLIQDPETV ; QHLDQHSDSK ; 100: QGKYLNWDAA ; FRFLQKYIQK ; ETECLRTAKQ ; NVSASTQATR ; QKKMQEISSL ; 150: VKYFIKCANK ; RAPRLKCQEL ; LNYIMDTVRD ; SSNNPIYGAD ; YSNILLKDIL ; 200: SVRKYWCEIS ; QQQWRELFLI ; YFTLYLKPSQ ; DINRLLVARI ; IQAVTKGCCS ; 250: QTDGLNSEFL ; DFFTKAIQNA ; RQEKSSPGLN ; HILAAYVIFL ; KTLAANFRIR ; 300: VCELGDKILP ; TLLYIWTQHR ; LNDSLKEVIV ; ELFQLQVYMH ; HPKGAKTQEK ; 350: GAYESAKWKS ; ILYNLYDLLV ; NEISRIGSRG ; KYSSGSRNIA ; VKENLIELMA ; 400: DICHQVFNED ; TRSLEISQSY ; TTTQREFSDY ; NAPCKKRKIE ; LGWGVIKDHL ; 450: QKSQNDFDVV ; PWLQIATQLI ; SKYPASLPNC ; ELSPLLMILY ; QLLPQQRRGE ; 500: RTPYVLRCLM ; EVALCQGKKP ; NLESSHKSDL ; LKIWIKIWSI ; TFRGISSEQI ; 550: QAENFGLLGA ; IIQGSLVEVD ; REFWKLFTGS ; ACKPSCPTVC ; CLTLALKTCV ; 600: VPETVETGME ; NICDGNRKFS ; LKESIMKWLL ; FCQLEDDFED ; RIELPPILHS ; 650: NFPHLALEKI ; LVSLIMKNCK ; AAMNFFQSVP ; ECEQHQKDTE ; EPSLLEVEEL ; 700: FLQTTFDKMD ; FLTVVQECTI ; EKHQSSVGFS ; FHQNLKESLD ; RYLLGLSEQL ; 750: LNNYLPETSD ; SETLVRCSSL ; LVGVLGCYCY ; VGVIAEEEAY ; TSELFQKAKS ; 800: LMQCAGESIT ; LFKSKTNEES ; RIISLRNMMH ; LCTNCLYKCA ; KRSPNKIASG ; 850: FFLRLLTSKL ; MHDIADVCRS ; LAFIIKKPFD ; CREVESMEDD ; TDKNLMEMND ; 900: QSSMSLFNDN ; PASSVIDANE ; SGESQITMGA ; MNPLAEEHLS ; KQDLLVLDML ; 950: RFLCMCITIA ; QSNTMSFRAA ; DIRRKLLMLI ; DSDRLDPTKS ; LHLHMYLVLL ; 1000: KELPGEEYPL ; PMEDVVELLK ; PLSSVCSLYR ; RDQDVCKTIL ; NHVLHIVPNL ; 1050: CRENVDAEST ; RDAQGQFLTV ; IGAFWHLTKE ; GKCTFSVRLA ; LVKCLKTLLE ; 1100: ADPYSRWAIL ; NVMEKDFPVN ; EVFPQFLADN ; HHQVCMLAAG ; LINRLFQHMK ; 1150: QGDSSTIMRA ; LPLKLQQTAF ; ENAYLKAQER ; IRQVKSQGGE ; NRELLDEICN ; 1200: RKAVLLTMIA ; VVLCCSPVCE ; KQALFALCKS ; VKENGLEPHL ; IKKVLEKVSE ; 1250: TFGYRHLEDF ; MASHLDYLVL ; EWLHLQDAEY ; SLSSFPFILL ; NYTNIEDFYR ; 1300: SCYKVLIPHL ; VMRCHFDEVK ; SIANQIQGDW ; KSLLTDCFPK ; ILVNILPYFA ; 1350: YEDTGDRGMA ; QQRETASKVY ; DMLKDENLLG ; KQIDQLFINN ; LPEIVVELLM ; 1400: TLHEPATSDA ; SQSTDPCDFS ; GDLDPRPNPP ; HFPSHVIKAT ; FAYISNCHKT ; 1450: KLKSILEVLS ; KSPDSYQKIL ; LAICEQAAET ; NNVYKKHRIL ; KIYHLFVSLL ; 1500: LKDMKSGLGG ; AWAFVLRDVI ; YTLIHYINKR ; PSRFMDVSLR ; SFSLCCDLLS ; 1550: RVCHTAVTYS ; KDALESHLHV ; IVGTLIPLVD ; GQMEVQKQVL ; DLLKYLVIDN ; 1600: KDNENLYVMI ; KLLDPFPDNA ; VFKDLRITQQ ; EIKYSKGPFS ; LLEEINHFLS ; 1650: VSVYDALPLT ; RLEGLKDLRR ; QLAQHKDQMM ; DLMRASQDNP ; QDGIVVKLVV ; 1700: SLLQLSKMAV ; NHTGEREVLE ; AVGRCLGEVG ; PIDFSTIAIQ ; HSKDMPYTKA ; 1750: LELFEDKEHH ; WTLMMLTYLN ; STLVEDCVKV ; RSAAVTCLKS ; ILATKTGHGF ; 1800: WEIFKTTADP ; MLTYLLPFRT ; SRKKFLEVPR ; LNKESPLEGL ; DDISLWIPQS ; 1850: ENHDIWIKTL ; TCALLDSGGI ; NSEVLQLLKP ; MCEVKTDFCQ ; TVLPYLIHDI ; 1900: LLQDTNESWR ; SLLSTHIQGF ; FTNCFRHSSQ ; TSRSTTPANM ; DSESEHVFRC ; 1950: HLDKKSQRTM ; LAVVDYMRRQ ; KRSSSGTVFD ; DAFWLELNYL ; EVAKVAQSCA ; 2000: AHFTALLYAE ; IYADKKNMDD ; QEKRSPTFEE ; GSQSTTISSL ; SEKSKEETGI ; 2050: SLQDLLLEIY ; RSIGEPDSLY ; GCGGGKMLQP ; LTRLRTYEHE ; AMWGKALVTY ; 2100: DLETAISSST ; RQAGIIQALQ ; NLGLCHILSV ; YLKGLDHENK ; EQCAELQELH ; 2150: YQVAWRNMQW ; DSCVSVNKGM ; EGTSYHESLY ; NALQSLRDRE ; FSTFYESLKY ; 2200: ARVKEVEELC ; KGSLESVYSL ; YPTLSRLQAI ; GELENIGELF ; SRSVTDRQPS ; 2250: EVYNKWWKHS ; QLLKDSDFSF ; QEPIMALRTV ; ILEILMEKEM ; ENSQRECLKD ; 2300: ILTKHLVELS ; LLARTFQNTQ ; LPERAIFQIK ; QYNSANCGVS ; EWQLEEAQVF ; 2350: WAKKEQSLAL ; SILKQMIKKL ; DASCTENDPR ; LKLIHIECLR ; VCGTWLAETC ; 2400: LENPAVIMQT ; YLEKAVELAG ; NYDGESNDEL ; RNGKMKAFLS ; LARFSDTQYQ ; 2450: RIENYMKSSE ; FENKQALLKR ; AKEEVGLLRE ; HKIQTNRYTI ; KVQRELELDE ; 2500: GALRALKKDR ; KRFLCKAVEN ; YINCLLSGEG ; HDMWIFRLCS ; LWLENSGVSE ; 2550: VNGMMKRDGM ; KIPSYKFLPL ; MYQLAARMGT ; KMMGGLGFHD ; VLNSLISRIS ; 2600: VDHPHHTLFI ; ILALANANKD ; EFLTKPEAAR ; SSRITKNTPK ; ESSQLDEDRT ; 2650: EAANKVICTL ; RNRRRQMVRS ; VEALCDAYII ; LANLDATQWR ; TQRKGIRIPA ; 2700: DQPITKLKNL ; EDVVVPTMEI ; KVDPTGEYGN ; MVTIQSFKPE ; FRLAGGLNLP ; 2750: KIIDCVGSDG ; KERRQLVKGR ; DDLRQDAVMQ ; QVFQMCNTLL ; QRNTETRKRK ; 2800: LTICTYKVVP ; LSQRSGVLEW ; CTGTVPIGEY ; LVNNDTGAHK ; RYRPKDFSPV ; 2850: QCQKKMMEAQ ; NKSFEEKYEI ; FMNICQNFQP ; VFRYFCMEKF ; LDPAVWFERR ; 2900: LAYTQSVATS ; SIVGYILGLG ; DRHVQNILIN ; EQSAELVHID ; LGVAFEQGKI ; 2950: LPTPETVPFR ; LTRDIVDGMG ; ITGVEGVFRR ; CCEKTMEVMR ; NSQETLLTIV ; 3000: EVLLYDPLFD ; WTMNPLKALY ; LQQRPEDESE ; LHSTPRADDQ ; ECKRNLSDTD ; 3050: QSFNKVAERV ; LMRLQEKLKG ; VEEGTVLSVG ; GQVNFLIQQA ; MDPKNLSKLF ; 3057: SGWKAWV
Sequence Length	3057
String	Q6PQD5
Sub Unit	Dimers or tetramers in inactive state. On DNA damage, autophosphorylation dissociates ATM into monomers rendering them catalytically active. Binds DNA ends, p53/TP53, ABL1, BRCA1, NBN/nibrin and TERF1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. DNA damage promotes association with RAD17. Interacts with EEF1E1; the interaction, induced on DNA damage, upregulates TP53. Interacts with DCLRE1C, MYST1, KAT5, OBFC2B, ATMIN and CEP164 (By similarity). Interacts with AP2B1 AND AP3B2; the interaction occurs in cytoplasmic vesicles (By similarity). Interacts with DDX1. Interacts with TELO2 AND TTI1.

Uniprot	Q6PQD5
Gene Name	ATM
Immunogen Species	Sus Scrofa (Pig)
Kegg	ssc:100101922
Unigene	Ssc.21876

Reference	1. "Genomic organization and comparative analysis of the porcine ataxia-telangiectasia mutated (ATM) gene." Fritz K.L., Rogatcheva M.B., Counter C.M., Schook L.B., Beever J.E. Submitted (2006-05) to the EMBL/GenBank/DDBJ databases [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]

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