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Home / Biochemicals / Small Molecules

(-)-Bicuculline methiodide

SKU : BHB21300054

An Antagonist of GABA(A) Receptors

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Mfr.No.	B-136, B-136_10 mg, B-136_25 mg, B-136_5 mg, B-136_50 mg
Description	(-)-Bicuculline methiodide (#B-136) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C21H20INO6.
Background	(-)-Bicuculline methiodide is a synthetic compound that acts as a water soluble GABA(A) receptor antagonist. The compound is a quaternary salt of bicuculline (BIC), a competitive antagonist of the GABA(A) receptors. (-)-Bicuculline methiodide is more stable at physiological pH and more soluble in aqueous solutions than bicuculline. The compound was shown to affect other neurotransmitter systems such as the cholinergic system1.GABA(A) receptors are members of the Cys-loop superfamily of ligand-gated ion channels. They mediate GABA (gamma-aminobutyric acid) action, a major inhibitory neurotransmitter, through the central nervous system (CNS). They play an important role in inhibiting cell excitation in the CNS. They are considered to be a major target of antiseizure drugs2,3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. Repeat freeze-thawing may result in loss of activity
Cas Number	40709-69-1
Molecular Weight	509.27
Solubility	Up to 20 mM in water. Also soluble in DMSO and ethanol. Centrifuge all product preparations before use (10000 x g, 5 min).
Target	GABA(A) receptors
Source	Synthetic
Activity	(-)-Bicuculline methiodide is a water soluble quaternary salt of Bicucculine, a competitive antagonist of the GABAA receptors (IC50 = 8.4 uM)1. Quaternary salts of Bicucculine were shown to have effects not mediated by GABA receptors2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (6R)-6-((5S)-6,6-dimethyl-7,8-dihydro-5H-(1,3)dioxolo(4,5-g)isoquinolin-6-ium-5-yl)-6H-furo(3,4-g)(1,3)benzodioxol-8-one;iodide.

Purity	>96% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Seutin, V. and Johnson S.W. (1999) Trends Pharmacol. Sci. 20, 268. Pomara, N. et al. (2015) Prog. Neuropsychopharmacol. Biol. Psychiatry 56, 35. Iqbal, F. et al. (2011) Bioorg. Med. Chem. Lett. 21, 4252. Horne, A.L. et al. (1992) Br. J. Pharmacol. 107, 732. Seutin, V. and Johnson S.W. (1999) Trends Pharmacol. Sci. 20, 268.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300054-1	B-136_10 mg	10 mg	$76		Add to Cart
BHB21300054-2	B-136_25 mg	25 mg	$151		Add to Cart
BHB21300054-3	B-136_5 mg	5 mg	$57		Add to Cart
BHB21300054-4	B-136_50 mg	50 mg	$210		Add to Cart

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