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Home / Biochemicals / Small Molecules

(S)-ATPO

SKU : BHB21300021

An Antagonist of AMPA/Kainate Receptors

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Mfr.No.	A-330, A-330_10 mg, A-330_25 mg, A-330_5 mg
Description	(S)-ATPO (#A-330) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C11H19N2O7P.
Synonyms	Synthetic
Background	ATPO, a phosphono amino acid, is a structural hybrid between the NMDA antagonist (RS)-2-amino-7-phosphonoheptanoic acid (AP7) and the AMPA and GluR5 agonist, (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl) propionic acid (ATPA).(S)-ATPO acts as a potent and selective AMPA and kainate receptor antagonist. ATPO has the ability to competitively reduce peak responses evoked by semi-rapid applications of AMPA1. It antagonizes AMPA-induced depolarization in the cortical wedge preparation with an IC50 value of 15 uM1.AMPA receptors are the principal glutamate receptors that mediate fast excitatory neurotransmission. This function is essential for synaptic plasticity and cellular correlate of learning and memory. Antagonists of AMPA receptors are good drug candidates for potential treatment of several neurological disorders such as epilepsy, stroke and amyotrophic lateral sclerosis (ALS)2,3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-500 uM.
Reconstitution	Up to 100 mM in 1eq NaOH. Centrifuge all products before reconstitution (10000 x g 5 min).
Cas Number	252930-37-3
Molecular Weight	322.25
Solubility	Up to 100 mM in 1eq NaOH. Centrifuge all products before reconstitution (10000 x g 5 min).
Target	AMPA/Kainate receptors
Activity	An active enantiomer of ATPO, an antagonist of GluR1-4 and a partial agonist of GluR5. (S)-ATPO antagonized AMPA-induced depolarization in the cortical wedge preparation with (IC50 =15 uM)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2S)-2-amino-3-(5-tert-butyl-3-(phosphonomethoxy)-1,2-oxazol-4-yl)propanoic acid.

Purity	>95%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C. It is recommended to aliquot reconstituted stock solutions.

Product Manual	SDS

Reference	Møller, E.H. et al. (1999) Chirality 11, 752. Guntupalli, S. et al. (2016) Neural. Plast. 2016, 3204519. Niu, L. et al. (2015) Acta. Pharm. Sin. B. 5, 500. Møller, E.H. et al. (1999) Chirality 11, 752.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300021-1	A-330_10 mg	10 mg	$730		Add to Cart
BHB21300021-2	A-330_25 mg	25 mg	$1631		Add to Cart
BHB21300021-3	A-330_5 mg	5 mg	$406		Add to Cart

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