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Home / Biochemicals / Small Molecules

1-EBIO

SKU : BHB21300129

A Potent Activator of KCa3.1 and KCa2 Channels

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Alomone Labs

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Mfr.No.	E-150, E-150_10 mg, E-150_100 mg, E-150_25 mg, E-150_250 mg, E-150_50 mg
Description	1-EBIO (#E-150) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C9H10N2O.
Synonyms	Synthetic
Background	1-EBIO is a potent KCa2/3 channel activator that activates the channels by increasing the Ca2+ sensitivity by stabilizing the interaction between calmodulin and the channels1,2, thus shifting the activation curve of the channels to the left. 1-EBIO activates KCa3.1 with an EC50 value of around 30 uM and all three KCa2 channels with EC50 value around 300 uM2.The Ca2+-activated K+ channel, KCa3.1, plays a major role in the controlled expression of essential genes that are responsible for several physiological processes including- membrane potential, cell volume proliferation, migration and production of inflammatory mediators by participating in the regulation of calcium entry. A highly regulated and sustained increase in cytosolic Ca2+ is critical in these processes making KCa3.1 a potential target for therapy of several disease1,3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	5-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	10045-45-1
Molecular Weight	162.19
Solubility	250 mM DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	KCa3.1, KCa2 channels
Activity	1-EBIO is an activator of KCa3.1 and KCa2 channel currents1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 3-ethyl-1H-benzimidazol-2-one.

Purity	>97%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Wong, R. et al. (2014) J. Neurosci. 34, 13371. Coleman, N. et al. (2014) Mol. Pharmacol. 86, 342. Strøbæk, D. et al. (2013) Br. J. Pharmacol. 168, 432. Waschk, D.E. et al. (2011) Am. J. Physiol. Cell. Physiol. 300, C843.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300129-1	E-150_10 mg	10 mg	$31		Add to Cart
BHB21300129-2	E-150_100 mg	100 mg	$202		Add to Cart
BHB21300129-3	E-150_25 mg	25 mg	$66		Add to Cart
BHB21300129-4	E-150_250 mg	250 mg	$406		Add to Cart
BHB21300129-5	E-150_50 mg	50 mg	$117		Add to Cart

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