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Home / Biochemicals / Small Molecules

2-Methyl-5-hydroxytryptamine hydrochloride

SKU : BHB21300219

An Agonist of 5-HT3 and 5-HT6 Receptors

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Alomone Labs

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Mfr.No.	M-170, M-170_10 mg, M-170_25 mg, M-170_5 mg, M-170_50 mg
Description	2-Methyl-5-hydroxytryptamine hydrochloride (#M-170) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C11H15ClN2O.
Synonyms	Synthetic
Background	Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.Methyl Serotonin (2-Methyl-5-hydroxytryptamine hydrochloride) is an agonist of 5-HT3 receptors with an effective concentration of 0.5-50 uM and an IC50 of 3.1±0.9 uM and also a potent ligand of the 5-HT6 receptor, member of the G-protein coupled receptor superfamily. Methyl Serotonin mimics the action of 5-HT although it displays a low affinity to 5-HT1 and 5-HT2 receptors. Methyl Serotonin was found to stimulate the hydrolysis of phosphoinositide in rat brain tissue2. In a study conducted in N1E-115 neuroblastoma cells, Methyl Serotonin elicited inward ion currents that were only 19.9±2.4% of currents elicited by regular Serotonin binding. These currents increase with higher concentration of Methyl serotonin. Desensitization of the 5-HT receptor after Methyl Serotonin binding was slower than equivalent Serotonin binding3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.5-50 uM.
Reconstitution	100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	845861-49-6
Molecular Weight	226.7
Solubility	100 mM in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT3 and 5-HT6 receptors
Activity	Methyl serotonin is a 5-HT3 agonist (Ki = 1200 nM) and potent 5-HT6 ligand (Ki = 46 nM)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 3-(2-aminoethyl)-2-methyl-1H-indol-5-ol;hydrochloride.

Purity	>97%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Hannon, J. and Hoyer, D. (2008) Behav. Brain Res. 195, 198. Edwards, E. et al. (1991) Brain Res. 545, 276. Sepulveda, M.I. et al. (1991) Br. J. Pharmacol. 104, 536. Craig, D.A. et al. (1990) Naunyn Schmiedebergs Arch. Pharmacol. 342, 9.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300219-1	M-170_10 mg	10 mg	$98		Add to Cart
BHB21300219-2	M-170_25 mg	25 mg	$219		Add to Cart
BHB21300219-3	M-170_5 mg	5 mg	$66		Add to Cart
BHB21300219-4	M-170_50 mg	50 mg	$399		Add to Cart

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