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Home / Biochemicals / Small Molecules

3-AQC

SKU : BHB21300007

An Antagonist of 5-HT3 Channels

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Alomone Labs

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Mfr.No.	A-205, A-205_10 mg, A-205_25 mg, A-205_5 mg, A-205_50 mg
Description	3-AQC (#A-205) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C20H21N5O4.
Background	Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand gated ion channel receptor of the cys-loop channel family. It is a pentamer with five subunits surrounding a central channel1.3-AQC is a potent and selective antagonist of the 5-HT3A channel. 3-AQC is a derivative of Piperazinyquinoxaline synthetically designed to be 100 times more potent in blocking Serotonin receptors than Tropisetron.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	149685-89-2
Molecular Weight	395.41
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT3A channel
Source	Synthetic
Activity	3-AQC is a potent and selective 5-HT3A receptor antagonist1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 3-(4-allylpiperazin-1-yl)-2-quinoxalinecarbonitrile maleate.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Hannon, J. and Hoyer, D. (2008) Behav. Brain Res. 195, 198. Monge, A. et al. (1993) J. Med. Chem. 36, 2745. Monge, A. et al. (1993) J. Med. Chem. 36, 2745.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300007-1	A-205_10 mg	10 mg	$151		Add to Cart
BHB21300007-2	A-205_25 mg	25 mg	$337		Add to Cart
BHB21300007-3	A-205_5 mg	5 mg	$98		Add to Cart
BHB21300007-4	A-205_50 mg	50 mg	$611		Add to Cart

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