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Home / Biochemicals / Small Molecules

5-Chloroindole

SKU : BHB21300087

A Positive Allosteric Modulator of 5-HT3 Receptors

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Alomone Labs

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Mfr.No.	C-260, C-260_1 g, C-260_5 g
Description	5-Chloroindole (#C-260) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C8H6ClN.
Background	5-Chloroindole is a potent and selective allosteric modulator of the 5-HT3 receptor that displays micromolar potency.The 5-HT3 receptor belongs to the Cys-loop ligand-gated ion channel superfamily. It mediates fast synaptic neurotransmission in neurons of both the central and peripheral nervous systems.5-Chloroindole can assist in the investigation of the molecular basis for allosteric modulation of the 5-HT3 receptor and may contribute to the discovery of novel therapeutic drugs targeting the 5-HT3 receptor1. 5-Chloroindole is also used as a strong inhibitor of the copper dissolution in acidic sodium chloride solution2. Several different studies have shown that 5-chloroindole has the ability to decrease serotonin levels in the brainstem and in the telencephalon3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	17422-32-1
Molecular Weight	151.6
Solubility	200 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT3 receptors
Source	Synthetic
Activity	5-Chloroindole is a potent and selective allosteric modulator of the 5-HT3 receptor that displays micromolar potency1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 5-chloro-1H-indole.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Newman, A.S. et al. (2013) Br. J. Pharmacol. 169, 1228. Scendo, M. et al. (2003) J. Appl. Electrochem. 33, 287. Sherman, A.D. and Gál, E.M. (1976) Psychopharmacol. Commun. 2, 285. Newman, A.S. et al. (2013) Br. J. Pharmacol. 169, 1228.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300087-1	C-260_1 g	1 g	$50		Add to Cart
BHB21300087-2	C-260_5 g	5 g	$213		Add to Cart

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