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Home / Biochemicals / Small Molecules

5-(N,N-Dimethyl)amiloride hydrochloride

SKU : BHB21300119

A Blocker of TRPA1 Channels and Selective Blocker of Na+/H+ and Na+/Ca2+ Exchangers

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Mfr.No.	D-165, D-165_10 mg, D-165_100 mg, D-165_25 mg, D-165_5 mg, D-165_50 mg
Description	5-(N,N-Dimethyl)amiloride hydrochloride (#D-165) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C8H13Cl2N7O.
Synonyms	Synthetic
Background	5-(N,N-Dimethyl)amiloride hydrochloride (DMA) is an amiloride derivative that selectively inhibits Na+/H+ exchangers in cellular membranes, resulting in the retention of H+ ions and in the decrease of intracellular pH. Amiloride derivatives are commonly used for their diuretic and antihypertensive properties.Several studies have reported that DMA has positive effects in pancreatic beta-cells on insulin release as a result of mis-regulation of intracellular pH and enhanced insulin secretion. Thus, amiloride derivatives are promising potential therapeutic agents for Type 2 Diabetes. In addition, positive effects on other cell functions have been demonstrated such as, cell membrane electrical activity, increase in intracellular Ca2+ and retention of K+1. DMA also enables glucose to induce time-dependent potentiation and enables it to occur in situations where it is normally absent1,2. Another study has suggested the possibility of DMA protection of the heart against post-resuscitation myocardial injury3.DMA also has the ability to inhibit the Na+/Ca2+ exchanger and to increase its currents in rat cardiomyocytes. Experimental trials have showed that DMA increases calcium sensitivity in normal and hypertrophied cardiomyocytes4.DMA also blocks TRPA1 channels5.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Up to 50 mM in methanol. Centrifuge all product preparations before use (5,000 x g for 1 min).
Cas Number	1214-79-5
Molecular Weight	294.1
Solubility	Up to 50 mM in methanol. Centrifuge all product preparations before use (5,000 x g for 1 min).
Target	TRPA1 channel, Na+/H+ and Na+/Ca2+ exchangers
Activity	5-(N,N-Dimethyl)amiloride hydrochloride blocks TRPA1 channels with an IC50 of 80 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 3-amino-6-chloro-N-(diaminomethylidene)-5-(dimethylamino)pyrazine-2-carboxamide;hydrochloride.

Purity	>99% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Gunawardana, S.C. et al. (2008) Am. J. Physiol. 294, 1097. Gunawardana, S.C. et al. (2005) BMC Endocr. Disord. 5, 9. Soliman, M. (2009) J. Saudi Heart Assoc. 21, 159. Cui, X.L. et al. (2002) Sheng Li Xue Bao. 54, 219. Banke, T.G. (2011) Brain Res. 1381, 21. Banke, T.G. (2011) Brain Res. 1381, 21.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300119-1	D-165_10 mg	10 mg	$85		Add to Cart
BHB21300119-2	D-165_100 mg	100 mg	$595		Add to Cart
BHB21300119-3	D-165_25 mg	25 mg	$184		Add to Cart
BHB21300119-4	D-165_5 mg	5 mg	$50		Add to Cart
BHB21300119-5	D-165_50 mg	50 mg	$333		Add to Cart

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