JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

A-192621

SKU : BHB21300027

A Selective Antagonist of Endothelin B Receptors

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	A-360, A-360_1 mg, A-360_10 mg, A-360_25 mg, A-360_5 mg
Description	A-192621 (#A-360) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C33H38N2O6.
Background	A-192621 is a synthetic compound that acts as a selective antagonist of the endothelin B (ET-B) receptor, a member of the G-protein coupled receptor (GPCR) superfamily.In vivo efficacy studies showed that A-192621 inhibits ET-1-induced dilatory and pressor responses that are mediated by ET-B. The compound can cause an increase in arterial blood pressure and plasma ET-1 levels1,2. It inhibits ET-B receptors with an IC50 value of 4.5 nM3.ET-B receptors play an important role in regulating renal function and blood pressure and are expressed in sensory nerves. They are mainly present in medium- and large-sized cell bodies of human trigeminal ganglia4,5.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 nM.
Reconstitution	Soluble in DMSO or NaOH 1Eq. Centrifuge all products before use (10000 x g 5 min).
Cas Number	195529-54-5
Molecular Weight	558.68
Solubility	Soluble in DMSO or NaOH 1Eq. Centrifuge all products before use (10000 x g 5 min).
Target	ET-B receptor
Source	Synthetic
Activity	A-192621 is a selective antagonist of ET-B endothelin receptors, inhibiting ET-1 binding to ETA and ET-3 binding to ETB receptors with IC50 values of 4280 nM and 4.5 nM, respectively1.In vivo, A-192621 inhibits ETB-mediated dilatory and pressor responses induced by Sarafotoxin 6c (ED50 = 30 mg/kg), and causes an elevation of arterial blood pressure and plasma ET-1 level2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-(2-(2,6-diethylanilino)-2-oxoethyl)-2-(4-propoxyphenyl)pyrrolidine-3-carboxylic acid.

Purity	>97% (HPLC)
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Sakai, S. et al. (2016) Life Sci. 159, 116. Wessale, J.L. et al. (2002) Clin. Sci. 103, 112S. Wu-Wong, J.R. et al. (2002) Clin. Sci. 103, 418S. Saeki, T. et al. (1991) Biochem. Biophys. Res. Commun. 179, 286. Xie, C. and Wang, D.H. (2009) Hypertension 54, 1298. Wu-Wong, J.R. et al. (2002) Clin. Sci. 103, 418S. Wessale, J.L. et al. (2002) Clin. Sci. 103, 112S.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300027-1	A-360_1 mg	1 mg	$168		Add to Cart
BHB21300027-2	A-360_10 mg	10 mg	$917		Add to Cart
BHB21300027-3	A-360_25 mg	25 mg	$1616		Add to Cart
BHB21300027-4	A-360_5 mg	5 mg	$595		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.