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Home / Biochemicals / Small Molecules

A-740003

SKU : BHB21300037

A Potent and Selective Antagonist of P2X7 Receptors

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Alomone Labs

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Mfr.No.	A-420, A-420_10 mg, A-420_100 mg, A-420_25 mg, A-420_50 mg
Description	A-740003 (#A-420) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C26H30N6O3.
Synonyms	Synthetic
Background	A-740003 is a potent, selective, and competitive antagonist of the P2X7 receptor, with IC50 values of 18 nM and 44 nM for rat and human P2RX7, respectively1. The compound shows weak or no activity on other P2 receptors.A-740003 has the ability to reduce neuropathic pain and tumor growth in vivo. Systemic administration of A-740003 in rat produces dose-dependent antinociception in a spinal nerve ligation model1,2.The P2X receptor family includes seven receptor subtypes: P2X1-P2X7. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. They are highly expressed on immune cells including glial cells, macrophages and other antigen-presenting cells1,2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 nM - 1 uM.
Reconstitution	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	861393-28-4
Molecular Weight	474.55
Solubility	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	P2X7 receptors
Activity	A-740003 is a potent and selective competitive antagonist of P2X7 receptors with IC50 values of 18 nM, 44 nM and 0.68 uM for rat, human and mouse receptors, respectively. A-740003 reduces neuropathic pain and tumor growth in vivo1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-(1-((E)-((cyanoamino)-(quinolin-5-ylamino)methylidene)amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide.

Purity	>96% (HPLC)
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Honore, P. et al. (2006) J. Pharmacol. Exp. Ther. 319, 1376. Donnelly-Roberts, D.L. et al. (2009) Br. J. Pharmacol. 157, 1203. Honore, P. et al. (2006) J. Pharmacol. Exp. Ther. 319, 1376. Donnelly-Roberts, D.L. et al. (2009) Br. J. Pharmacol. 157, 1203.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300037-1	A-420_10 mg	10 mg	$50		Add to Cart
BHB21300037-2	A-420_100 mg	100 mg	$168		Add to Cart
BHB21300037-3	A-420_25 mg	25 mg	$66		Add to Cart
BHB21300037-4	A-420_50 mg	50 mg	$85		Add to Cart

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