JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

A-850002

SKU : BHB21300032

A Selective and Potent Antagonist of mGluR1 Receptors

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	A-390, A-390_10 mg, A-390_25 mg, A-390_5 mg, A-390_50 mg
Description	A-850002 (#A-390) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C18H16N4OS.
Synonyms	Synthetic
Background	A-850002 is a synthetic, selective and potent antagonist of mGluR1 receptors. It inhibits mGluR1 receptors in rat primary cerebellar granule neurons with an IC50 value of 27 nM in calcium mobilization assays and human mGluR1 receptors expressed in 1321N1 type cells with an IC50 of 43 nM1,2.Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors that play an important role in synaptic plasticity and other neuro-physiological and pathological processes including a major role in central sensitization and neuropathic pain. Type 1 mGluRs are mainly found on post-synaptic neurons and are known to affect the fate of neuronal progenitor cells, neural stem cells and the formation of the hippocampus3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 nM - 1 uM.
Reconstitution	Up to 25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	869802-73-3
Molecular Weight	336.41
Solubility	Up to 25 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	mGluR1 receptor
Activity	A-850002 inhibits mGluR1 in rat primary cerebellar granule neurons with an IC50 of 27 nM1 and human mGluR1 expressed in 1321N1 cells with an IC50 of 43 nM2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 9-(dimethylamino)-3-(4-methylphenyl)pyrido(2,3)thieno(2,4-d)pyrimidin-4-one.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C.

Product Manual	SDS

Reference	Zhu, C.Z. et al. (2008) Eur. J. Pharmacol. 580, 314. Zheng, G.Z. et al. (2005) J. Med. Chem. 48, 7374. Eom, H.S. et al. (2016) PLoS One 11, e0147538. Zhu, C.Z. et al. (2008) Eur. J. Pharmacol. 580, 314. Zheng, G.Z. et al. (2005) J. Med. Chem. 48, 7374.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300032-1	A-390_10 mg	10 mg	$235		Add to Cart
BHB21300032-2	A-390_25 mg	25 mg	$468		Add to Cart
BHB21300032-3	A-390_5 mg	5 mg	$168		Add to Cart
BHB21300032-4	A-390_50 mg	50 mg	$843		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.