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Home / Biochemicals / Small Molecules

A23187

SKU : BHB21300049

Widely Used Ca2+ Ionophore

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Alomone Labs

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Mfr.No.	A-600, A-600_1 mg, A-600_10 mg, A-600_5 mg
Description	A23187 (#A-600) is a highly pure, natural, and biologically active compound.
Molecular Formula	C29H37N3O6.
Synonyms	Natural
Background	A23187 is a mobile-carrier Ca2+ ionophore (allows Ca2+ ions to cross cell membranes) originally isolated as an antibiotic from Streptomyces chartreusensis. It is used to increase intracellular Ca2+ levels and for in vitro studies related to intracellular Ca2+-mediated events. A23187 can cause cell activation, differentiation, or proliferation and thus mimics cellular processes observed in response to cytokines and growth factors.1,2Furthermore, A23187 induces, in a concentration- and time-dependent manner, Ca2+-triggered cell apoptosis.3,4 This property was exploited to clarify apoptotic events in different cell lines such as mouse lymphoma cell line (S49),5,6 histiocytic lymphoma U937,7 human myeloid leukemia cells (HL-60),8 cultured striatal neurons,9 renal tubular cells,10 and C6 glioma cells.11
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-10 uM.
Reconstitution	DMSO, ethanol or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	52665-69-7
Molecular Weight	523.6
Solubility	DMSO, ethanol or methanol. Centrifuge all product preparations before use (10000 x g 5 min).
Activity	A23187 is a mobile-carrier Ca2+ ionophore and can cause cell activation, differentiation, or proliferation and thus mimics cellular processes observed in response to cytokines and growth factors1,2. Furthermore, A23187 induces, in a concentration- and time-dependent manner, Ca2+ triggered cell apoptosis3,4.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 5-(Methylamino)-2-((2R,3R,6S,8S,9R,11R)-3,9,11- trimethy l-8-((1S)-1-methyl-2-oxo-2-(1H-pyrrol-2-yl)-ethyl)-1,7- dioxaspiro(5.5)undec-2-yl)methyl)-4-benzoxazolecarboxylic acid.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to one week at 4°C or three months at -20°C.Protect from light.

Product Manual	SDS

Reference	Berridge, M.J. (1993) Nature 361, 315. Scharff, O. et al. (1993) Physiol. Rev. 73, 547. Orrenius, S. et al. (2003) Nat. Rev. Mol. Cell Biol. 4, 552. Hajnoczky, G. et al. (2003) Biochem. Biophys. Res. Commun. 304, 445. Caron-Leslie, L.A. et al. (1991) Mol. Endocrinol. 5, 1169. Caron-Leslie, L.A. et al. (1994) FASEB J. 8, 639. Rzigalinski, B.A. et al. (1994) Biochim. Biophys. Acta. 1223, 219. Vrana, J.A. et al. (1998) Int. J. Oncol. 12, 927. Petersen, A. et al. (2000) Brain Res. 857, 20. Cheng, C.H. et al. (2002) FEBS Lett. 516, 191. Jansen, S. et al. (2003) Biol. Trace Elem. Res. 96, 133. Berridge, M.J. (1993) Nature 361, 315. Scharff, O. et al. (1993) Physiol. Rev. 73, 547. Orrenius, S. et al. (2003) Nat. Rev. Mol. Cell Biol. 4, 552. Hajnoczky, G. et al. (2003) Biochem. Biophys. Res. Commun. 304, 445.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300049-1	A-600_1 mg	1 mg	$55		Add to Cart
BHB21300049-2	A-600_10 mg	10 mg	$149		Add to Cart
BHB21300049-3	A-600_5 mg	5 mg	$91		Add to Cart
BHB21300049-4	A-600_1 mg	10x1 mg	$317		Add to Cart
BHB21300049-5	A-600_5 mg	5x5 mg	$355		Add to Cart

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