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Home / Biochemicals / Small Molecules

AACBA hydrochloride

SKU : BHB21300035

A Potent and Selective Antagonist of P2X7 Receptors

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Alomone Labs

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Mfr.No.	A-410, A-410_10 mg, A-410_25 mg, A-410_5 mg, A-410_50 mg
Description	AACBA hydrochloride (#A-410) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C23H33Cl2N3O (C23H32ClN3O · HCl).
Synonyms	Synthetic
Background	AACBA hydrochloride is a potent and selective antagonist of P2X7 receptors. It inhibits human and rat P2X7 receptors with IC50 values of 18 nM and 29 nM, respectively1.AACBA reduces interleukin-6 release in a dose-dependent manner and prevents or reverses carrageenan-induced paw edema and mechanical hypersensitivity in acute in vivo models of pain and inflammation1.P2X receptors are a family of ion channels gated by ATP, a ubiquitous energy donor and receptor ligand in living cells. P2X receptors are widely expressed in neuronal, muscular, epithelial and immune cells and play a pivotal role in models of various pain conditions. P2X7 receptor mediates the release of proinflammatory cytokines known to have roles in inflammatory/immune conditions and pain1,2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 nM.
Reconstitution	Soluble up to 200 mM in water. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	1101868-22-7
Molecular Weight	438.43
Solubility	Soluble up to 200 mM in water. Centrifuge all products before handling (10000 x g 5 min).
Target	P2X7 receptors
Activity	AACBA hydrochloride is a potent and selective antagonist of P2X7 receptors, shown to inhibit human and rat P2X7 receptors with IC50 values of 18 nM and 29 nM, respectively. Active in vivo on acute models of pain and inflammation1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-(Adamantan-1-ylmethyl)-5-((3R-aminopyrrolidin-1-yl)methyl)-2-chloro-benzamide hydrochloride.

Purity	>99%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Broom, D.C. et al. (2008) J. Pharmacol. Exp. Ther. 327, 620. Pijacka, W. et al. (2016) Nat. Med. 10, 1151. Broom, D.C. et al. (2008) J. Pharmacol. Exp. Ther. 327, 620.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300035-1	A-410_10 mg	10 mg	$287		Add to Cart
BHB21300035-2	A-410_25 mg	25 mg	$627		Add to Cart
BHB21300035-3	A-410_5 mg	5 mg	$168		Add to Cart
BHB21300035-4	A-410_50 mg	50 mg	$969		Add to Cart

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