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Home / Biochemicals / Small Molecules

Aconitine

SKU : BHB21300002

An Activator of NaV Channels

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Alomone Labs

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Mfr.No.	A-150, A-150_100 mg, A-150_25 mg, A-150_250 mg, A-150_50 mg
Description	Aconitine (#A-150) is a highly pure, natural, and biologically active compound.
Molecular Formula	C34H47NO11.
Synonyms	Natural
Background	Voltage-gated sodium channels (NaV) are present in most excitable cell membranes and play an important role in generating action potentials. A variety of toxins and chemicals are known to either block or modulate Na+ channels and have proven to be invaluable in investigating the physiological characteristics of these channels1. Most notably, tetrodotoxin (TTX), a potent and selective blocker of Na+ channels, binds to neurotoxin receptor site 1 to block them2.Aconitine is a diterpense two-ester alkaloid derived from the tubers of aconitinum plants and has been used as traditional herbal medicine in China and Japan since ancient times. Modern pharmacological studies have shown that aconitine has effects of analgesia and anesthesia, anti-inflammatory, immune regulation, anti-tumor and cardiotonic actions3,4. Concurrently, aconitine also presents enormous toxicity5. It is well known for its toxic effects on the heart and central nervous system where it causes cardiac arrhythmias, systemic paralysis and coma6. Aconitine alters the kinetics and voltage dependence of Na+ channel activation, inhibits Na+ channel inactivation through binding to neurotoxin receptor site 2 and causes persistent activation of Na+ channels at the resting membrane potential7.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM - 1 uM.
Reconstitution	DMSO, ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	302-27-2
Molecular Weight	645.74
Solubility	DMSO, ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Target	NaV Na+ channels
Activity	Aconitine modulates voltage-dependent sodium channels in a complex way1. It activates the channel at low voltages, while at high voltages its effects appear inhibitory.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol 8-acetate 14-benzoate.

Purity	>98% (HPLC)
Form	Lyophilized Powder
Storage	Storage After Reconstitution: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Wright, S.N. (2002) J. Physiol. 538, 759. Cestele, S. and Catterall, W.A. (2000) Biochimie 82, 883. Ameri A. (1998) Prog. Neurobiol. 56, 211. Mizugaki, M. et al. (1998) J. Anal. Toxicol. 22, 336. Zhang. L. et al. (2007) J. Sep. Sci. 30, 1357. Ulbricht, W. (1998) Rev. Physiol. Biochem. Pharmacol. 133, 1. Suzuki, Y. et al. (1994) Planta Med. 60, 391. Rao, S. and Sikdar, S.K. (2000) Pflügers Arch. 439, 349.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300002-1	A-150_100 mg	100 mg	$457		Add to Cart
BHB21300002-2	A-150_25 mg	25 mg	$184		Add to Cart
BHB21300002-3	A-150_250 mg	250 mg	$900		Add to Cart
BHB21300002-4	A-150_50 mg	50 mg	$286		Add to Cart

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