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Home / Biochemicals / Small Molecules

ACT-462206

SKU : BHB21300041

A Potent Antagonist of Orexin1/2 Receptors

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Alomone Labs

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Mfr.No.	A-450, A-450_10 mg, A-450_25 mg, A-450_5 mg, A-450_50 mg
Description	ACT-462206 (#A-450) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C20H24N2O4S
Synonyms	Synthetic
Background	ACT-462206 is a potent, brain-penetrant dual orexin 1/orexin 2 receptor antagonist with IC50 values of 60 nM and 11 nM, respectively. It has been subjected to clinical trials for use as a sleep inducer1.Orexins are highly conserved proteins known to control feeding behavior, sleep-wake rhythm, reward and addiction, and energy balance. In addition, several reports show that orexin/receptor pathways are involved in pathological processes of neurological diseases such as narcolepsy, depression, ischemic stroke, drug addiction and Alzheimer's disease2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM - 5 uM
Reconstitution	Soluble up to 100 mM in DMSO. Spin down all products before handling.
Cas Number	1361321-96-1
Molecular Weight	388.48
Solubility	Soluble up to 100 mM in DMSO. Spin down all products before handling.
Target	OX1, OX2 orexin receptors
Activity	ACT-462206 is a potent and selective dual orexin receptor antagonist (IC50 of 60 nM and 11 nM on orexin 1 and 2 receptors, respectively). ACT-462206 is brain penetrant and orally bioavailable, demonstrating anxiolytic-like properties in rodents without affecting cognition and motor function1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2S)-N-(3,5-dimethylphenyl)-1-(4-methoxyphenyl)sulfonylpyrrolidine-2-carboxamide

Purity	>98%
Form	Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C for several months. It is recommended to aliquot stock solutions to avoid repeated thawing and freezing.

Product Manual	SDS

Reference	Hoch, M. et al. (2014) J. Clin. Pharmacol. 54, 979. Spinazzi, R. et al. (2006) Pharmacol. Rev. 58, 46. Boss, C., et al (2014) ChemMedChem. 9, 2486.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300041-1	A-450_10 mg	10 mg	$298		Add to Cart
BHB21300041-2	A-450_25 mg	25 mg	$596		Add to Cart
BHB21300041-3	A-450_5 mg	5 mg	$180		Add to Cart
BHB21300041-4	A-450_50 mg	50 mg	$960		Add to Cart

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