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Home / Biochemicals / Small Molecules

Amentoflavone

SKU : BHB21300003

A Negative Allosteric Modulator of GABA(A) Receptors

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Mfr.No.	A-165, A-165_1 mg, A-165_10 mg, A-165_25 mg, A-165_5 mg
Description	Amentoflavone (#A-165) is a highly pure, natural, and biologically active compound.
Molecular Formula	C30H18O10.
Synonyms	Natural
Background	Amentoflavone is a natural compound derived from the plant Selaginella tamariscina. It is a negative allosteric modulator of GABA(A) receptors. Amentoflavone can be found in a number of plants with medicinal properties including Ginkgo biloba and Hypercium perforatum. Amentoflavone is the first high affinity ligand known for the benzodiazepine receptor devoid of nitrogen in its structure. It has been hypothesized recently that amentoflavone can cross the blood brain barrier in vivo by passive diffusion. In addition to its effect on GABA receptors, amentoflavone inhibits binding at 5-HT, D3-dopamine and delta-opioid receptors. The action of amentoflavone on the GABA(A) receptor is independent of high affinity benzodiazepine modulatory sites on the receptor. Amentoflavone and other substances of the flavone class have been found to exert anxiolytic activity in mice without the side effect associated with the use of benzodiazepines1.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.5 nM - 0.5 uM.
Reconstitution	50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	1617-53-4
Molecular Weight	538.46
Solubility	50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	GABA(A) receptors
Activity	Amentoflavone is a negative allosteric modulator of GABA(A) receptor inhibitory activity, with EC50=4 uM on recombinant alpha1beta2gamma2L GABA(A) in oocytes1. In vitro, it potently displaces benzodiazepine binding to rat brain membranes with nM affinity2, and inhibits binding at other GPCRs3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 8-(5-(5,7-dihydroxy-4-oxochromen-2-yl)-2-hydroxyphenyl)-5,7-dihydroxy-2-(4-hydroxyphenyl)chromen-4-one.

Purity	>=98.5%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Hanrahan, J.R. et al. (2003) Bioorg. Med. Chem. Lett. 13, 2281. Hanrahan, J.R. et al. (2003) Bioorg. Med. Chem. Lett. 13, 2281. Nielsen, M. et al. (1988) Biochem. Pharmacol. 37, 3285. Butterweck, V. et al. (2002) Psychopharmacology (Berl.) 162, 193.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300003-1	A-165_1 mg	1 mg	$92		Add to Cart
BHB21300003-2	A-165_10 mg	10 mg	$266		Add to Cart
BHB21300003-3	A-165_25 mg	25 mg	$529		Add to Cart
BHB21300003-4	A-165_5 mg	5 mg	$192		Add to Cart

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