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Home / Biochemicals / Small Molecules

AP-18

SKU : BHB21300011

A Reversible TRPA1 Channel Blocker

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Alomone Labs

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Mfr.No.	A-250, A-250_10 mg, A-250_25 mg, A-250_5 mg, A-250_50 mg
Description	AP-18 (#A-250) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C11H12ClNO.
Synonyms	Synthetic
Background	The transient receptor potential (TRP) channel is one of the largest families of cation channels1. TRPA1 is expressed in sensory and nociceptive neurons and has a significant role in inflammatory responses. Bradykinin and histamine receptors induce TRPA1 activity. A study conducted found that TRPA1 deficient mice did not develop an elevated mechanical and thermal pain response following bradykinin injection, suggesting that TRPA1 has a vital role in bradykinin signaling pathways2.TRPA1 also plays a role in acute and chronic respiratory disease pathophysiology. Prolonged exposure to TRPA1 agonists such as chlorine and aldehydes can cause reactive airways dysfunction syndrome characterized by symptoms such as wheezing, coughing and dyspnea. In light of this, TRPA1 may be a target for airway anti-inflammatory research3.AP-18 is a reversible TRPA1 blocker with an IC50 value of 3.1 and 4.5 uM for human and rat TRPA1 channels respectively.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Cas Number	55224-94-7
Molecular Weight	209.7
Solubility	Up to 200 mM in DMSO. Centrifuge all product preparations before use (5,000 x g for 1 min).
Target	TRPA1 channels
Activity	AP-18 has an IC50 of 3.1 and 4.5 uM for human and mouse TRPA1, respectively1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (NE)-N-((Z)-4-(4-chlorophenyl)-3-methylbut-3-en-2-ylidene)hydroxylamine.

Purity	>99% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Levine, J.D. and Alessandri-Haber, N. (2007) Biochim. Biophys. Act. 1772, 989. Bautista, D.M. et al. (2006) Cell 124, 1269. Bessac, B.F. and Jordt, S. (2008) Physiology 23, 360. Petrus, M. et al. (2007) Mol. Pain 3, 40.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300011-1	A-250_10 mg	10 mg	$85		Add to Cart
BHB21300011-2	A-250_25 mg	25 mg	$184		Add to Cart
BHB21300011-3	A-250_5 mg	5 mg	$66		Add to Cart
BHB21300011-4	A-250_50 mg	50 mg	$337		Add to Cart

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