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Home / Biochemicals / Small Molecules

Arcaine sulfate

SKU : BHB21300018

An Antagonist of NMDA Receptors

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Alomone Labs

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Mfr.No.	A-285, A-285_100 mg, A-285_25 mg, A-285_50 mg
Description	Arcaine sulfate (#A-285) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C6H18N6O4S.
Background	Glutamate is the main excitatory neurotransmitter in the CNS and is also involved in a variety of pathological conditions including epilepsy. Glutamate binds to the ionotropic NMDA receptor to relay its excitatory signal.Arcaine sulfate is a competitive inhibitor of the NMDA receptor and also an inhibitor of the enzyme NO synthase. It has an effective concentration of 50-500 uM and an IC50 of 61 uM at -60 mV. Arcaine binds to the polyamine recognition site of the NMDA receptor complex and blocks the receptor in a concentration- and voltage-dependent manner. At positive membrane potentials Arcaine does not produce a blocking effect. In the presence of 100 uM Arcaine (at -60 mV), NMDA amplitude whole cell currents are reduced by 67% and by 69% in single channel recordings. The inhibitory effect of Arcaine is rapid in onset and recovery (
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	50-500 uM.
Reconstitution	20 mM in water. Centrifuge all product preparations before use (10,000 x g for 1 min).
Cas Number	14923-17-2
Molecular Weight	270.31
Solubility	20 mM in water. Centrifuge all product preparations before use (10,000 x g for 1 min).
Target	NMDA receptors
Source	Synthetic
Activity	Arcane is an NMDA receptor antagonist with KD of 61 uM at -60 mV1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-(4-(diaminomethylideneamino)butyl)guanidine;sulfuric acid.

Purity	>95%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Donevan, S.D. et al. (1992) Mol. Pharmacol. 41, 727. Donevan, S.D. et al. (1992) Mol. Pharmacol. 41, 727.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300018-1	A-285_100 mg	100 mg	$151		Add to Cart
BHB21300018-2	A-285_25 mg	25 mg	$66		Add to Cart
BHB21300018-3	A-285_50 mg	50 mg	$85		Add to Cart

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