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Home / Biochemicals / Small Molecules

Arvanil

SKU : BHB21300022

An Agonist of TRPV1 Channels and a Ligand of CB1 Receptors

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Mfr.No.	A-335, A-335_10 mg, A-335_100 mg, A-335_25 mg, A-335_50 mg
Description	Arvanil (#A-335) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C28H41NO3.
Synonyms	Synthetic
Background	Arvanil (N-Vanillylarachidonamide) is an agonist of TRPV1 channels and a ligand of CB1 cannabinoid receptors. Arvanil is a structural hybridization between the arachidonoyl group of anandamide (CB1 receptor ligand) and the vanillyl moiety of capsaicin1,2. Arvanil shows an EC50 value of 0.5 nM for TRPV1 receptors, and an IC50 value of 3.6 uM as an inhibitor of anandamide accumulation1.Studies have found that arvanil has the ability to induce dose-dependent apoptosis in the lymphoid Jurkat T-cell line2.CB1 receptors are important regulators of excitatory and inhibitory synaptic transmission in different areas in the brain. The receptor plays a crucial role in multiple sclerosis disease course and in mood control3.TRPV1 receptors are highly expressed in primary nociceptors. These channels can be activated by several stimuli such as heat, acid, certain arachidonic acid derivatives and direct phosphorylation via PKC4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 nM - 1 uM.
Reconstitution	Soluble in ethanol and DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	128007-31-8
Molecular Weight	439.64
Solubility	Soluble in ethanol and DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	TRPV1 channels, CB1 receptors
Activity	Arvanil is an agonist of TRPV1 channels (EC50 = 0.5 nM), a ligand of CB1 receptors (Ki = 0.25-0.5 uM), and an inhibitor of anandamide accumulation (IC50 = 3.6 uM). In vivo it demonstrates vasodilator, analgesic, and anti-inflammatory properties. Arvanil inhibits human breast cancer cell proliferation and the growth of astrocytoma xenograft tumors in mice1-3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (5Z,8Z,11Z,14Z)-N-((4-hydroxy-3-methoxyphenyl)methyl)icosa-5,8,11,14-tetraenamide.

Purity	>96% (HPLC)
Form	Liquid
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Melck, D. et al. (1999) Biochem. Biophys. Res. Commun. 262, 275. Sancho, R. et al. (2003) Br. J. Pharmacol. 140, 1035. Gentile, A. et al. (2016) J. Neuroinflammation 13, 231. McLeod, R.L. et al. (2006) Cough 2, 10. Melck, D. et al. (1999) Biochem. Biophys. Res. Commun. 262, 275. Di Marzo, V. et al. (2000) Eur. J. Pharmacol. 406, 363. Di Marzo, V. et al. (2002) J. Pharmacol. Exp. Ther. 300, 984.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300022-1	A-335_10 mg	10 mg	$50		Add to Cart
BHB21300022-2	A-335_100 mg	100 mg	$355		Add to Cart
BHB21300022-3	A-335_25 mg	25 mg	$111		Add to Cart
BHB21300022-4	A-335_50 mg	50 mg	$202		Add to Cart

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