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Home / Biochemicals / Small Molecules

ATPA

SKU : BHB21300044

A Potent and Selective Agonist of GluK1 Kainate Receptor

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Mfr.No.	A-480, A-480_10 mg, A-480_25 mg, A-480_5 mg, A-480_50 mg
Description	ATPA (#A-480) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C10H16N2O4.
Background	ATPA, an AMPA derivative, is a potent and selective agonist of the GluR5 (GluK1) kainate receptor subtype, with an EC50 value of 0.66 uM1. ATPA is less active towards other kainate receptor subtypes and is inactive towards GluR6. The compound also shows weak agonistic activities towards AMPA receptors1,2. Studies show that ATPA can induce clonic seizures when infused intravenously or directly into the rat amygdala3.GluR5 containing kainate receptors play an important role in the regulation of GABA(A) receptor-mediated inhibitory transmission in the hippocampus and in the amygdala3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.5-50 uM.
Reconstitution	Soluble in water, DMSO and 1eq NaOH. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	140158-50-5
Molecular Weight	228.25
Solubility	Soluble in water, DMSO and 1eq NaOH. Centrifuge all products before handling (10000 x g 5 min).
Target	GluK1 (GluR5) kainate receptors
Source	Synthetic
Activity	ATPA is a potent and selective agonist of GluR5 kainate receptor (EC50 = 0.66 uM), inactive on GluR6 and less active on other kainate receptor subtypes. It is also a significantly weaker agonist of AMPA receptors (EC50 = 8 uM-62 uM, depending on subtype)1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-azaniumyl-3-(5-tert-butyl-3-oxo-1,2-oxazol-4-yl)propanoate.

Purity	>96%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Nielsen, M.M. et al. (2003) Mol. Pharmacol. 63, 19. Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405. Figueiredo, T.H. et al. (2011) J. Pharmacol. Exp. Ther. 336, 303. Nielsen, M.M. et al. (2003) Mol. Pharmacol. 63, 19. Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300044-1	A-480_10 mg	10 mg	$168		Add to Cart
BHB21300044-2	A-480_25 mg	25 mg	$373		Add to Cart
BHB21300044-3	A-480_5 mg	5 mg	$117		Add to Cart
BHB21300044-4	A-480_50 mg	50 mg	$649		Add to Cart

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