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Home / Biochemicals / Small Molecules

Atrasentan

SKU : BHB21300042

A Potent and Selective Antagonist of Endothelin A Receptors

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Alomone Labs

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Mfr.No.	A-455, A-455_1 mg, A-455_10 mg, A-455_25 mg, A-455_5 mg, A-455_50 mg
Description	Atrasentan (#A-455) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C29H38N2O6.
Synonyms	Synthetic
Background	Atrasentan (A-127722) is a synthetic compound that acts as a potent and selective antagonist of endothelin A (ET-A) receptor. Atrasentan is highly selective towards ET-A receptor, exhibiting 1000-fold selectivity over ET-B receptors1. It inhibits endothelin-1 radioligand binding with an IC50 value of 0.36 nM and endothelin-1-stimulated phosphoinositol hydrolysis with an IC50 of 0.16 nM1.ET-A receptors are predominantly detected in peripheral tissues, especially in vascular smooth muscle tissues where they mediate vasoconstriction. They are also expressed in several regions of the brain. The ET-A receptor has high affinity for endothelin-1 and endothelin-2 and relatively low affinity for endothelin-3, while the ET-B receptor has high affinity for all endothelin isopeptides2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.01-10 nM.
Reconstitution	Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).
Cas Number	173937-91-2
Molecular Weight	510.62
Solubility	Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).
Target	ET-A receptors
Activity	Atrasentan is a potent and highly selective antagonist of ET-A endothelin receptors, exhibiting a 1000-fold selectivity for ET-A over ET-B receptors, inhibiting endothelin-1 radioligand binding with an IC50 of 0.36 nM and endothelin-1-stimulated phosphoinositol hydrolysis with IC50 of 0.16 nM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2R,3R,4S)-4-(1,3-benzodioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Winn, M. et al. (1996) J. Med. Chem. 39, 1039. Saeki, T. et al. (1991) Biochem. Biophys. Res. Commun. 179, 286. Winn, M. et al. (1996) J. Med. Chem. 39, 1039.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300042-1	A-455_1 mg	1 mg	$85		Add to Cart
BHB21300042-2	A-455_10 mg	10 mg	$287		Add to Cart
BHB21300042-3	A-455_25 mg	25 mg	$642		Add to Cart
BHB21300042-4	A-455_5 mg	5 mg	$219		Add to Cart
BHB21300042-5	A-455_50 mg	50 mg	$1019		Add to Cart

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