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Home / Biochemicals / Small Molecules

Avosentan

SKU : BHB21300026

A Selective Antagonist of Endothelin A Receptors

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Mfr.No.	A-355, A-355_10 mg, A-355_25 mg, A-355_5 mg, A-355_50 mg
Description	Avosentan (#A-355) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C23H21N5O5S.
Background	Avosentan is a synthetic compound that acts as a selective antagonist of endothelin A (ET-A) receptors. It was initially developed for the treatment of diabetic nephropathy1,2. Studies show that inhibition of ET-A receptors can be protective in chronic kidney disease through several processes including vasodilation, attenuation of proteinuria, and increasing diuresis2.ET-A receptors are predominantly detected in peripheral tissues, especially in vascular smooth muscle tissues where they mediate vasoconstriction. They are also expressed in several regions of the brain. The ET-A receptor has high affinity for endothelin-1 and endothelin-2 and relatively low affinity for endothelin-3, while the ET-B receptor has high affinity for all endothelin isopeptides3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-100 nM.
Reconstitution	Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).
Cas Number	290815-26-8
Molecular Weight	479.51
Solubility	Soluble in DMSO. Centrifuge all products before use (10000 x g 5 min).
Target	ET-A receptors
Source	Synthetic
Activity	Avosentan is a selective antagonist of ET-A endothelin receptors, shown to significantly inhibit endothelin-1-induced contractions in isolated porcine ciliary arteries at 10 nM-1 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-(6-methoxy-5-(2-methoxyphenoxy)-2-pyridin-4-ylpyrimidin-4-yl)-5-methylpyridine-2-sulfonamide.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Konieczka, K. et al. (2011) Curr. Eye Res. 36, 118. Baltatu, O.C. et al. (2012) Front. Physiol. 3, 103. Saeki, T. et al. (1991) Biochem. Biophys. Res. Commun. 179, 286. Konieczka, K. et al. (2011) Curr. Eye Res. 36, 118.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300026-1	A-355_10 mg	10 mg	$117		Add to Cart
BHB21300026-2	A-355_25 mg	25 mg	$263		Add to Cart
BHB21300026-3	A-355_5 mg	5 mg	$85		Add to Cart
BHB21300026-4	A-355_50 mg	50 mg	$476		Add to Cart

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