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Home / Biochemicals / Small Molecules

AZD-9056 hydrochloride

SKU : BHB21300038

A Potent and Selective Antagonist of P2X7 Receptors

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Alomone Labs

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Mfr.No.	A-425, A-425_1 mg, A-425_10 mg, A-425_25 mg, A-425_5 mg
Description	AZD-9056 hydrochloride (#A-425) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C24H36Cl2N2O2 (C24H35ClN2O2 · HCl).
Synonyms	Synthetic
Background	AZD-9056 hydrochloride is an adamantane amide that acts as a potent and selective antagonist of P2X7 receptors. It inhibits YoPro1 (membrane-impermeable fluorescent dye) uptake in HEK-hP2X7 cells with IC50 value of 11.2 nM1. Studies show that treatment with AZD-9056 exerts pain-relieving and anti-inflammatory effects1,2.The P2X7 receptor is a member of the ligand-gated ion channels activated by extracellular ATP. There are seven receptor subtypes: P2X1-P2X7. P2X7 receptors participate in a variety of cellular responses such as membrane permeabilization, activation of caspases, cytokine release, cell proliferation, and apoptosis. P2X7 receptors are highly expressed throughout autonomic, sensory and central neurons and in visceral smooth muscle, immune cells and epithelia3,4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 nM.
Reconstitution	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	345303-91-5
Molecular Weight	455.46
Solubility	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	P2X7 receptors
Activity	AZD-9056 is a potent and selective, orally bioavailable antagonist of the purinergic P2X7 receptor, shown to inhibit YoPro1 uptake in HEK-hP2X7 cells with IC50 of 11.2 nM1. AZD-9056 shows pain-relieving and anti-inflammatory effects in vivo2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-(1-adamantylmethyl)-2-chloro-5-(3-(3-hydroxypropylamino)propyl)benzamide hydrochloride.

Purity	>97%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Seeland, S. et al. (2015) Pharmacol. Res. Perspect. 3, e00123. Hu, H. et al. (2016) Int. J. Mol. Med. 38, 1922. Stokes, L. et al. (2006) Br. J. Pharmacol. 149, 880. Donnelly-Roberts, D.L. et al. (2009) Br. J. Pharmacol. 157, 1203 Seeland, S. et al. (2015) Pharmacol. Res. Perspect. 3, e00123. Hu, H. et al. (2016) Int. J. Mol. Med. 38, 1922.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300038-1	A-425_1 mg	1 mg	$85		Add to Cart
BHB21300038-2	A-425_10 mg	10 mg	$468		Add to Cart
BHB21300038-3	A-425_25 mg	25 mg	$933		Add to Cart
BHB21300038-4	A-425_5 mg	5 mg	$306		Add to Cart

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