BAY 11 7082

Mfr.No.	SIH-434
Alternative Names	Bay 11-7821, (E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile
Appearance	White solid
Function	IKK kinase inhibitor
Inchi	InChI=1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
Inchikey	DOEWDSDBFRHVAP-KRXBUXKQSA-N
Mode Of Action	Inhibitor
Molecular Formula	C10H9NO2S
Pubchem Cid	5353431
Sd File	C10H9NO2S APtclcactv07301412492D 0 0.00000 0.00000 23 23 0 0 0 0 0 0 0 0999 V2000 2.1340 -1.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8660 -1.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.1340 -2.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8660 -2.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0000 -3.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0000 -0.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0000 -2.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.0000 0.2500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 2.0000 0.2500 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0 3.0000 1.2500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8660 1.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.0000 0.2500 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0 3.8660 2.7500 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.8660 3.7500 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 2.4631 1.5600 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5970 -0.9400 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4030 -0.9400 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 1.5970 -2.5600 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4030 -2.5600 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 4.4030 1.4400 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 2.3800 -3.7500 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.0000 -4.3700 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 3.6200 -3.7500 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0 8 12 2 0 0 0 0 9 12 2 0 0 0 0 6 12 1 0 0 0 0 10 12 1 0 0 0 0 13 14 3 0 0 0 0 1 6 2 0 0 0 0 2 6 1 0 0 0 0 10 11 2 0 0 0 0 1 3 1 0 0 0 0 2 4 2 0 0 0 0 3 7 2 0 0 0 0 4 7 1 0 0 0 0 5 7 1 0 0 0 0 11 13 1 0 0 0 0 10 15 1 0 0 0 0 1 16 1 0 0 0 0 2 17 1 0 0 0 0 3 18 1 0 0 0 0 4 19 1 0 0 0 0 11 20 1 0 0 0 0 5 21 1 0 0 0 0 5 22 1 0 0 0 0 5 23 1 0 0 0 0 M END $$$$
Research Area	Cell Signaling ; Cancer ; Apoptosis ; Cancer Growth Inhibitors ; Tyrosine Kinase Inhibitors
Safety Phrases	Classification: Not a hazardous substance or mixture. Safety Phrases: S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection.
Smiles	C1=C([S](=O)(=O)C=CC#N)C=CC(=C1)C
Field Of Use	Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Cas Number	19542-67-7
Molecular Weight	207.3
Scientific Background	BAY 11 7082 inhibits cytokine induced IκBα phosphorylation and indirectly decreases NF-κb activity. It is also an E2 ubiquitin (Ub) conjugating enzyme inhibitor. BAY 11 7082 can also induce apoptosis.
Solubility	Soluble to 25 mM in ethanol and to 100 mM in DMSO
Source	Synthetic
Adr Code	Non-hazardous
Country Of Origin	Canada
Tarriff Code	3822.00.1090

Shipping Temperature	Shipped Ambient
Gross Weight (kg)	0.25
Net Weight (g)	0.01
Purity	≥98% (HPLC)
Storage Temperature	-20ºC
Stock Product	Y

Reference	1. Mori N., et al. (2002) Blood 100(5): 1828–1834. 2. Pierce J.W., et al. (1997) J.Biol.Chem. 272(34): 21096–21103.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB11900218-1	SIH-434-10MG	10 mg	$90		Add to Cart
BHB11900218-2	SIH-434-50MG	50 mg	$359		Add to Cart

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