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Home / Biochemicals / Small Molecules

Bilobalide

SKU : BHB21300057

An Antagonist of 5-HT3A and GABA(A) Receptors

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Mfr.No.	B-145, B-145_10 mg, B-145_25 mg, B-145_50 mg
Description	Bilobalide (#B-145) is a highly pure, natural, and biologically active compound.
Molecular Formula	C15H18O8.
Background	Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine neurotransmitter synthesized from the amino acid tryptophan by the enzyme tryptophan-decarboxylase. The 5-HT3 channel is a ligand-gated ion channel receptor of the Cys-loop channel family1.The GABA(A) receptor is also a ligand-gated ion channel. It is the major receptor type for the GABA inhibitory neurotransmitter in the central nervous system2.Bilobalide is a natural non-selective blocker of the 5-HT3A and GABA(A) channels. Bilobalide is a sesquiterpene trilactone extracted from the leaves of the tree Ginkgo biloba. Bilobalide has an effective concentration of 1-100 uM and an IC50 of 470 uM for the 5-HT3A receptor3 and an IC50 of 4.6±0.5 uM for the GABA(A) receptor. Bilobalide also binds to other anion Cys-loop receptors such as glycine receptors with a much higher affinity than to the 5-HT3A receptor.Bilobalide inhibits direct GABA mediated currents from recombinant human GABA(A) receptors thus suggesting it enhances neuronal excitability. Bilobalide is used in traditional Japanese medicine as a memory enhancer, treating symptoms associated with mild-moderate dementia and improving cognitive functions related to old age and senility3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity
Cas Number	###############################################################################################################################################################################################################################################################
Molecular Weight	326.3
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	5-HT3A, GABA(A) receptors
Source	Natural
Activity	Bilobalide is a 5-HT3A1 and GABAA2 channel blocker.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (5aR- (3aS,5aalpha,8b,8aS,9a,10aalpha))- 9-(1,1-dimethylethyl)- 10,10a-dihydro- 8,9-dihydroxy- 4H,5aH,9H-furo(2,3-b)furo(3',2':2,3)cyclopenta(1,2-c)furan- 2,4,7(3H,8H)-trione.

Purity	>99.5%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Hannon, J. et al. (2008) Behav. Brain Res. 195, 198. Olsen, R.W. et al. (1990) FASEB J. 4, 1469. Tompson, A.J. et al. (2011) Neuropharmacology 60, 488. Huang, S.H. et al. (2003) Eur. J. Pharmacol. 464, 1. Tompson, A.J. et al. (2011) Neuropharmacology 60, 488. Huang, S.H. et al. (2003) Eur. J. Pharmacol. 464, 1.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300057-1	B-145_10 mg	10 mg	$66		Add to Cart
BHB21300057-2	B-145_25 mg	25 mg	$145		Add to Cart
BHB21300057-3	B-145_50 mg	50 mg	$262		Add to Cart

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