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Home / Biochemicals / Small Molecules

BzATP triethylammonium salt

SKU : BHB21300031

An Agonist of P2X7 Receptors

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Mfr.No.	A-385, A-385_10 mg, A-385_25 mg, A-385_5 mg
Description	BzATP triethylammonium salt (#A-385) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C24H24N5O15P3 · C18H45N3.
Synonyms	Synthetic
Background	BzATP triethylammonium salt is an agonist of the purinergic P2X7 receptor that is ten times more potent than ATP1. On rat P2X7 receptor, BzATP triethylammonium salt demonstrates an EC50 value of 6.8 uM2. The compound also shows partial agonist activity on other P2X receptors1.P2X receptors are a family of ion channels gated by ATP, a ligand that mediates numerous physiological functions. P2X receptors are widely localized in cell types of almost every origin, including neuronal, muscular, epithelial and immune, and have been shown to play a pivotal role in models of various pain conditions2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.5-300 uM.
Reconstitution	Soluble up to 100 mM in water. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	112898-15-4
Molecular Weight	1018.97
Solubility	Soluble up to 100 mM in water. Centrifuge all products before handling (10000 x g 5 min).
Target	P2X7 receptors
Activity	BzATP triethylammonium salt is an agonist of the purinergic P2X7 receptor, more potent than ATP, with EC50 varying from 0.7 to 285 uM, depending on receptor species, buffer composition, serum constituents and repeated exposure to ATP. Shows partial agonist activity on other P2X receptors. Can be used as a photoaffinity label for ATPase1-3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: ((2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-((hydroxy-(hydroxy(phosphonooxy)phosphoryl)oxyphosphoryl)oxymethyl)oxolan-3-yl) 4-benzoylbenzoate;N,N-diethylethanamine.

Purity	>95%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Zhong, Y. et al. (1998) Br. J. Pharmacol. 125, 771. Hibell, A.D. et al. (2000) Br. J. Pharmacol. 130, 167. Bhattacharya, A. et al. (2013) Br. J. Pharmacol. 170, 624. Williams, N. and Coleman, P.S. (1982) J. Biol. Chem. 257, 2834. Zhong, Y. et al. (1998) Br. J. Pharmacol. 125, 771. Hibell, A.D. et al. (2000) Br. J. Pharmacol. 130, 167.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300031-1	A-385_10 mg	10 mg	$202		Add to Cart
BHB21300031-2	A-385_25 mg	25 mg	$355		Add to Cart
BHB21300031-3	A-385_5 mg	5 mg	$117		Add to Cart

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