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Home / Biochemicals / Small Molecules

Camptothecin

SKU : BHB21300095

Topoisomerase Inhibitor

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Alomone Labs

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Mfr.No.	C-330, C-330_100 mg, C-330_250 mg, C-330_50 mg, C-330_500 mg
Description	Camptothecin (#C-330) is a highly pure, natural, and biologically active compound.
Molecular Formula	C20H16N2O4.
Background	Camptothecin is an anti-cancer alkaloid that specifically inhibits DNA topoisomerase I and DNA topoisomerase II (topoisomerase I/II).1-3 The highly conserved region around Gly505 of topoisomerase I was found to be important for camptothecin activity.4Camptothecin converts topoisomerase into a cell poison by trapping the cleavable covalent complex of enzyme with duplex DNA and blocking the re-ligation step. Thereby enhancing and stabilizing the formation of DNA breakage which is responsible for cell death.1-9Camptothecin inhibits (IC50 = 30 nM) Tat protein-mediated transactivation of HIV-1 and enhances PKCa activity during apoptosis in HL60 myeloid leukemia cells via a caspase-regulated mechanism.9,10
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-300 nM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	########
Molecular Weight	348.36
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Source	Natural
Activity	Camptothecin is an alkaloid that specifically inhibits DNA topoisomerase I/II and is an anticancer agent1,2. It also promotes apoptosis in a caspase-dependent manner3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (S)-4-Ethyl-4-hydroxy-1H-pyrano-(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage of solutions: Up to two weeks at 4°C or six months at -20°C.

Product Manual	SDS

Reference	Hsiang, Y.H. et al. (1985) J. Biol. Chem. 260, 14873. Capranico, G. et al. (1990) Nucleic Acids Res. 18, 6611. Chen, A.Y., and Liu, L.F. (1994) Annu. Rev. Pharmacol. Toxicol. 34, 191. Tanizawa, A. et al. (1993) J. Biol. Chem. 268, 25463. Wang, J.C. (1996) Annu. Rev. Biochem. 65, 635. Kaufmann, S.H. (1998) Biochim. Biophys. Acta. 1400, 195. Pommier, Y. et al. (1998) Biochim. Biophys. Acta. 1400, 83. Jaxel, C. et al. (1991) J. Biol. Chem. 266, 20418. Li, C.J. et al. (1994) J. Biol. Chem. 269, 7051. Shao, R.G. et al. (1997) J. Biol. Chem. 272, 31321. Hsiang, Y.H. et al. (1985) J. Biol. Chem. 260, 14873. Capranico, G. et al. (1990) Nucleic Acids Res. 18, 6611. Cotter, T.G. et al. (1992) Anticancer Res. 12, 773.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300095-1	C-330_100 mg	100 mg	$50		Add to Cart
BHB21300095-2	C-330_250 mg	250 mg	$85		Add to Cart
BHB21300095-3	C-330_50 mg	50 mg	$31		Add to Cart
BHB21300095-4	C-330_500 mg	500 mg	$117		Add to Cart

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