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Home / Biochemicals / Small Molecules

Cantharidic Acid

SKU : BHB21300085

A Potent Inhibitor of Protein Phosphatase 1 and Protein Phosphatase 2A

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Mfr.No.	C-250, C-250_1 mg
Description	Cantharidic Acid (#C-250) is a highly pure, semi-synthetic, and biologically active compound.
Molecular Formula	C10H14O5Na2.
Background	Cantharidic acid is a lipophilic structural analogue of Cantharidin (#C-170), isolated from Mylabris phalerata (Chinese blister beetle)1. Similarly to Cantharidin, Cantharidic acid is a specific inhibitor of serine/threonine protein phosphatases 1 and 2A. Cantharidic acid was found to be 5 to 12 times more potent against the catalytic subunit of protein phosphatase 2A than the catalytic subunit of protein phosphatase 11. Cantharidic acid is widely used to study the role of protein phosphatases in the regulation of various physiological functions2-4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM - 1 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is lyophilized in 0.5 ml conical vial. The product is soluble in pure water to high-micromolar concentrations (5 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity. Avoid exposure to light.
Cas Number	28874-45-5
Molecular Weight	258.18
Solubility	DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Source	Semi-synthetic
Activity	Cantharidic acid is a potent inhibitor of PP1 and PP2A (IC50 = 50 nM)1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Chemical Name: 5 -3 2,3-Dicarboxy-2,3-dimethyl-1,4-epoxycyclohexane, exo-1,6-Dicarboxy-endo-1,6-dimethyl-7-oxabicylco(2,2,1)heptane.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to two weeks at 4°C or six months at -20°C.

Product Manual	SDS

Reference	Li, Y.M. et al. (1993) Biochem. Pharmacol. 46, 1435. Hong, S.J. (2000) Br. J. Pharmacol. 130,1211. Krautheim, A. et al. (2000) Br. J. Pharmacol. 129, 687. Laidley, C.W. et al. (1997) J. Pharmacol. Exp. Ther. 280, 1152. Li, Y.M. and Casida, J.E. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 11867.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300085-1	C-250_1 mg	1 mg	$129		Add to Cart
BHB21300085-2	C-250_1 mg	5x1 mg	$506		Add to Cart

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