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Home / Biochemicals / Small Molecules

Capsaicin

SKU : BHB21300073

A Powerful TRPV1 Agonist

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Alomone Labs

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Mfr.No.	C-125, C-125_1 g, C-125_100 mg, C-125_25 mg, C-125_250 mg, C-125_50 mg
Description	Capsaicin (#C-125) is a highly pure, Synthetic, and biologically active compound.
Molecular Formula	C18H27NO3.
Synonyms	Synthetic
Background	Vanilloid receptor 1 (VR1, TRPV1) is a nonselective cation channel that is activated by heat and acid, as well as vanilloids1,2.Capsaicin is a TRPV1 agonist, which acts directly on TRPV13. Being small and hydrophobic, capsaicin crosses the plasma membrane readily to reach its intracellular ligand-binding site on TRPV1, leading to channel activation and cation permeation4-6.Capsaicin acts directly on TRPV11, with half-maximal effective concentration of 711.9 nM in Xenopus oocytes3 and 0.29 uM in HEK293 cells7.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 uM.
Reconstitution	Ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	404-86-4
Molecular Weight	305.4
Solubility	Ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Target	TRPV1 channels
Activity	Capsaicin is one of the most powerful chemical agonists of the TRPV1 (transient receptor potential vanilloid) channel. It is a small lipophilic molecule derived from hot chili peppers that acts on sensory neurons by opening TRPV1, a principal transduction channel for nociception1. Capsaicin acts directly on TRPV12, with half-maximal effective concentration of 711.9 nM in Xenopus oocytes3 and 0.29 uM in HEK293 cells4.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (E)-N-((4-Hydroxy-3-methoxyphenyl)methyl)-8-methyl-6-nonenamide.

Purity	>98% (HPLC)
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to one week at 4°C or six months at -20°C.

Product Manual	SDS

Reference	0 Caterina, M.J. et al. (1997) Nature 389, 816. Tominaga, M. et al. (1998) Neuron 21, 531. Vriens, J. et al. (2009) Mol. Pharmacol. 75, 1262. Li, H. et al. (2011) Proc. Natl. Acad. Sci. U.S.A. 108, 8497. Jordt, S.E. and Julius, D. et al. (2002) Cell 108, 421. Jung, J. et al. (1999) J. Neurosci. 19, 529. McNamara, F.N. et al. (2005) Br. J. Pharmacol. 144, 781. Weltzin, M.M. and Schulte, M.K. et al. (2010) J. Pharmacol. 334, 917. Li, H. et al. (2011) Proc. Natl. Acad. Sci. U.S.A. 108, 8497. Vriens, J. et al. (2009) Mol. Pharmacol. 75, 1262. Caterina, M.J. et al. (1997) Nature 389, 816. McNamara, F.N. et al. (2005) Br. J. Pharmacol. 144, 781.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300073-1	C-125_1 g	1 g	$626		Add to Cart
BHB21300073-2	C-125_100 mg	100 mg	$119		Add to Cart
BHB21300073-3	C-125_25 mg	25 mg	$75		Add to Cart
BHB21300073-4	C-125_250 mg	250 mg	$235		Add to Cart
BHB21300073-5	C-125_50 mg	50 mg	$86		Add to Cart

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