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Home / Biochemicals / Small Molecules

Capsazepine

SKU : BHB21300072

A Selective TRPV1 Blocker and an Activator of ENaCgamma Channels

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Mfr.No.	C-120, C-120_10 mg, C-120_25 mg, C-120_5 mg, C-120_50 mg
Description	Capsazepine (#C-120) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C19H21ClN2O2S.
Background	Capsazepine is a synthetic, competitive and selective antagonist of TRPV1 (transient receptor potential vanilloid 1)1 and an activator of amiloride-sensitive epithelial Na+ channel gamma (ENaCgamma). It also inhibits K+-dependent ATP hydrolysis with no effect on Na+-ATPase2,3.Capsazepine is being used in in vitro and in vivo pharmacological studies as a standard TRPV1 competitive antagonist.Capsazepine exhibits potent inhibition of expression of the iNOS gene in LPS-stimulated murine macrophages through inactivation of NF-kappaB4.The amiloride-sensitive epithelial Na+ channel (ENaC) regulates Na+ homeostasis into cells and across epithelia5.TRPV1 is a member of a distinct subgroup of transient receptor potential (TRP) ion channels. These channels are highly expressed on primary nociceptors and can be activated by several different stimuli such as heat, acid, certain arachidonic acid derivatives and direct phosphorylation via PKC6.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-100 uM.
Reconstitution	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	138977-28-3
Molecular Weight	376.9
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	TRPV1, ENaCgamma channels
Source	Synthetic
Activity	Capsazepine is a selective antagonist of the vanilloid VR1 receptor (TRPV1) with IC50 of 40 nM, and an activator of the ENaC channels.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-(2-(4-chlorophenyl)ethyl)-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide.

Purity	>97%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Vriens, J. et al. (2009) Mol. Pharmacol. 75, 1262. Shukla, A. et al. (2014) PLoS One 9, e100797. Mahmmoud, Y.A. et al. (2014) PLoS One 9, e96909. Gonzalez-Reyes, L.E. et al. (2013) Exp. Neurol. 250, 321. Yamamura, H. et al. (2004) J. Biol. Chem. 279, 44483. McLeod, R.L. et al. (2006) Cough 2, 10. Vriens, J. et al. (2009) Mol. Pharmacol. 75, 1262.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300072-1	C-120_10 mg	10 mg	$66		Add to Cart
BHB21300072-2	C-120_25 mg	25 mg	$145		Add to Cart
BHB21300072-3	C-120_5 mg	5 mg	$50		Add to Cart
BHB21300072-4	C-120_50 mg	50 mg	$263		Add to Cart

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