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Home / Biochemicals / Small Molecules

CAY10593 (VU0155069)

SKU : BHB21300102

An Antagonist of P2X7 Receptors and an Inhibitor of Phospholipase D1

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Mfr.No.	C-385, C-385_10 mg, C-385_25 mg, C-385_5 mg, C-385_50 mg
Description	CAY10593 (VU0155069) (#C-385) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C26H27ClN4O2.
Synonyms	Synthetic
Background	CAY10593 (VU0155069) is an antagonist of purinergic P2X7 receptors and an inhibitor of phospholipase D1 (PLD1)1. CAY10593 inhibits ATP-induced ethidium+ uptake in RPMI 8226 cells expressing P2X7 receptors in a concentration-dependent manner with an IC50 value of 2 uM1.The P2X receptors are a family of ligand-gated ion channels present on various cell types. P2X receptors are activated by extracellular ATP and play an important role in many disease states, including inflammatory, immune, neoplastic, musculoskeletal, and neurological disorders1,2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-10 uM.
Reconstitution	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	1130067-06-9
Molecular Weight	462.98
Solubility	Soluble in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	P2X7 receptors, Phospholipase D1 (PLD1)
Activity	CAY10593 (VU0155069) is an antagonist of purinergic P2X7 receptors, shown to inhibit ATP-induced ethidium+ uptake in RPMI 8226 cells with IC50 of 2 uM1. It is also a potent and selective inhibitor of phospholipase D1 (IC50 of 46 and 933 nM for PLD1 and PLD2, respectively)2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-((2S)-1-(4-(5-chloro-2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl)propan-2-yl)naphthalene-2-carboxamide.

Purity	>95%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Pupovac, A. et al. (2013) Purinergic Signal. 9, 609. Lewis, J.A. et al. (2009) Bioorg. Med. Chem. Lett. 19, 1916. Pupovac, A. et al. (2013) Purinergic Signal. 9, 609. Lewis, J.A. et al. (2009) Bioorg. Med. Chem. Lett. 19, 1916.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300102-1	C-385_10 mg	10 mg	$184		Add to Cart
BHB21300102-2	C-385_25 mg	25 mg	$373		Add to Cart
BHB21300102-3	C-385_5 mg	5 mg	$117		Add to Cart
BHB21300102-4	C-385_50 mg	50 mg	$595		Add to Cart

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