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Home / Biochemicals / Small Molecules

CGP-37849

SKU : BHB21300094

A Potent and Selective Antagonist of NMDA Receptors

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Mfr.No.	C-325, C-325_10 mg, C-325_25 mg, C-325_5 mg, C-325_50 mg
Description	CGP-37849 (#C-325) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C6H12NO5P.
Background	CGP-37849 is a synthetic compound that acts as a potent, selective, and competitive antagonist of N-methyl-d-aspartate (NMDA) receptors. CGP 37849 shows significant central effects following oral administration to animals. CGP-37849 is used to elucidate the roles of NMDA receptors in brain function, and as therapeutic agents for the treatment of neurological disorders such as epilepsy and ischemic brain damage in humans1.NMDA receptors are heterotetrameric channels formed by the assembly of two obligatory GluN1 and two GluN2/GluN3 subunits. They play important roles in a variety of cellular processes and brain functions such as synaptic plasticity, addiction, and stroke. NMDA receptors mediate physiological functions such as learning and memory formation and participate in glutamate excitotoxicity2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-100 nM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	127910-31-0
Molecular Weight	209.14
Solubility	Up to 50 mM in water. May require gentle warming. Centrifuge all product preparations before use (10000 x g 5 min).
Target	NMDA receptors
Source	Synthetic
Activity	CGP-37849 is a potent and selective antagonist of NMDA receptors, inhibiting the binding of selective NMDA ligand (3H)-CPP to rat brain NMDA with Ki of 35 nM. Orally bioavailable anticonvulsant in vivo1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (E)-2-amino-4-methyl-5-phosphonopent-3-enoic acid.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Store at -20°C. It is recommended to prepare solutions afresh on the day of use, or aliquot stock solutions stored at -20°C to prevent repeated thawing.

Product Manual	SDS

Reference	Fagg, G.E. et al. (1990) Br. J. Pharmacol. 99, 791. Black, S.A. et al. (2014) Front. Cell Dev. Biol. 2, 45. Fagg, G.E. et al. (1990) Br. J. Pharmacol. 99, 791.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300094-1	C-325_10 mg	10 mg	$134		Add to Cart
BHB21300094-2	C-325_25 mg	25 mg	$297		Add to Cart
BHB21300094-3	C-325_5 mg	5 mg	$85		Add to Cart
BHB21300094-4	C-325_50 mg	50 mg	$537		Add to Cart

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