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Home / Biochemicals / Small Molecules

Chelerythrine chloride

SKU : BHB21300104

An Inhibitor of Protein Kinase C, SERCA Pump, and P2X7 Receptor

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Alomone Labs

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Mfr.No.	C-400, C-400_1 mg, C-400_5 mg
Description	Chelerythrine chloride (#C-400) is a highly pure, natural, and biologically active compound.
Molecular Formula	C21H18ClNO4.
Background	Chelerythrine is a potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM) that binds to the catalytic domain of PKC. Chelerythrine is at least 100-fold more selective for PKCs than for other kinases.1,2In platelets, Chelerythrine inhibits thromboxane formation and phosphoinositide metabolism.3,4 It has an inhibitory effect on ACh-induced current in PC12 cells.5Chelerythrine induces apoptotic cell death in polymorphonuclear leukocyte through activation of caspase-3.6 Furthermore, Chelerythrine treated cells underwent apoptosis, with features that suggest involvement of the mitochondrial pathway, and through a mechanism that involves inhibition of the anti-apoptotic inhibitor BclXL.7Chelerythrine inhibits SERCA pumps with an IC50 of 1.5 uM8. It also antagonizes P2X7 receptors; it inhibits ATP-induced 86Rb+ efflux with an IC50 of 5.6 uM9.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-5 uM.
Reconstitution	Water or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	3895-92-9
Molecular Weight	383.84
Solubility	Water or DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	PKC, SERCA pumps, P2X7 receptor
Source	Natural
Activity	Chelerythrine chloride is a potent, cell-permeable inhibitor of protein kinase C (PKC). It is at least 100-fold more selective for PKCs than for other kinases1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1,2-Dimethoxy-12-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: Store the reconstituted solution for the shortest time possible at -20°C. We do not recommend storing the product in working solution for longer than one day. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to two weeks at 4°C or six months at -20°C.

Product Manual	SDS

Reference	Herbert, J.M. et al. (1990) Biochem. Biophys. Res. Commun. 172, 993. Chao, M.D. et al. (1998) Planta Med. 64, 662. Ko, F.N. et al. (1990) Biochim. Biophys. Acta 1052, 360. Le Corvoisier, P. et al. (2002) Fundam. Clin. Pharmacol. 16, 31. Shi, L. and Wang, Ca. (1999) Arch. Biochem. Biophys. 368, 40. Sweeney, J.F. et al. (2000) Shock 13, 464. Chan, S.L. et al. (2003) J Biol. Chem. 278, 20453. Vieira, S.M. et al. (2015) Arch. Biochem. Biophys. 570, 58. Shemon, A.N. et al. (2004) Br. J. Pharmacol. 142, 1015. Herbert, J.M. et al. (1990) Biochem. Biophys. Res. Commun. 172, 993. Chao, M.D. et al. (1998) Planta Med. 64, 662.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300104-1	C-400_1 mg	1 mg	$55		Add to Cart
BHB21300104-2	C-400_5 mg	5 mg	$167		Add to Cart
BHB21300104-3	C-400_1 mg	5x1 mg	$206		Add to Cart

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