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Home / Biochemicals / Small Molecules

Cilnidipine

SKU : BHB21300075

A Blocker of L- and N-Type CaV Channels

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Alomone Labs

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Mfr.No.	C-135, C-135_10 mg, C-135_25 mg, C-135_5 mg, C-135_50 mg
Description	Cilnidipine (#C-135) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C27H28N2O7.
Background	Cilnidipine (CIL) is a potent slow-acting, anti-sympathetic drug that inhibits N-type (IC50 = 200 nM) and L-type (IC50 = 100 nM) Ca2+ channels and thus alleviates hypertension occurrences. CIL is essentially a dihydropyridine with slow onset and long-term vasodilation effects. It is considered to be a "fourth generation" anti-hypertension drug, effective both in vivo and in vitro1,2-4.In vivo studies have demonstrated CIL to be helpful in mitigating long QT syndrome in a canine model and to reduce ischemic cardiac norepinephrine levels in rabbit model of cardiac infraction. Clinical trials have shown that CIL is highly effective in cases of severe hypertension, that it improves left ventricular function, and is effective in combating hypertension5-8.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 1 min).
Cas Number	132203-70-4
Molecular Weight	492.5
Solubility	10 mM in DMSO. Centrifuge all product preparations before use (10000 x g 1 min).
Target	L- and N-type Ca2+ channels
Source	Synthetic
Activity	Cilnidipine is an L- and N-type Ca2+-channel blocker1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester.

Purity	>98.5%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Takahara, A. (2009) Cardiovasc. Ther. 27, 124. Fujii, S. et al. (1997) J. Pharmacol. Exp. Ther. 280, 1184. Lohn, M. et al. (2002) J. Hypertens. 20, 885. Kokilambigai, K.S. and Lakshmi, K.S. (2014)? Int. J. Pharm. Pharm. Sci. 6, 36. Hoshide, S. et al. (2005) Hypertens. Res. 28, 1003. Nagai, H. et al. (2005) Hypertens. Res. 28, 361. Ashizawa, N. et al. (2007) Int. Heart. J. 48, 597. Tan, H.W. et al. (2006) J. Hum. Hypertens. 20, 618. Furukawa, T. et al. (1999) J. Pharmacol. Exp. Ther. 291, 464.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300075-1	C-135_10 mg	10 mg	$85		Add to Cart
BHB21300075-2	C-135_25 mg	25 mg	$151		Add to Cart
BHB21300075-3	C-135_5 mg	5 mg	$66		Add to Cart
BHB21300075-4	C-135_50 mg	50 mg	$287		Add to Cart

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