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Home / Biochemicals / Small Molecules

CIQ

SKU : BHB21300088

A Selective Potentiator of GluN2C/GluN2D-Containing NMDA Receptors

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Mfr.No.	C-275, C-275_10 mg, C-275_100 mg, C-275_25 mg, C-275_5 mg, C-275_50 mg
Description	CIQ (#C-275) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C26H26ClNO5.
Synonyms	Synthetic
Background	CIQ is a positive allosteric potentiator selective for NR2C- and NR2D-containing N-methyl-d-aspartate (NMDA) receptors. The compound does not potentiate other NMDA receptor subtypes or AMPA and kainate receptors. The activity of CIQ depends on a single residue in the M1 region of the receptor1,2. CIQ demonstrates potentiating EC50 values of 2.7 and 2.8 uM for NR2C- and NR2D-containing receptors, respectively1.NMDA receptors are tetrameric entities composed of two obligatory GluN1 and two GluN2 subunits. They play important roles in numerous cellular processes and brain functions such as synaptic plasticity, addiction, and stroke. NMDA receptors also mediate physiological functions such as learning and memory formation. They are also involved in many neurodegenerative conditions including Alzheimer's disease2,3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Concentration	1-20 uM.
Cas Number	486427-17-2
Molecular Weight	467.95
Solubility	Soluble in DMSO up to 100 mM. Centrifuge all products before handling (10000 x g 5 min).
Target	NMDA receptors
Activity	CIQ is an NR2C and NR2D selective potentiator of NMDA receptors. It enhances receptor responses two-fold with EC50 of 3 uM by increasing channel opening frequency1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes

Purity	>99% (HPLC)
Form	Lyophilized Powder
Storage	Storage of solutions: Store at -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Suryavanshi, P.S. et al. (2014) Br. J. Pharmacol. 171, 799. Black, S.A. et al. (2014) Front. Cell Dev. Biol. 2, 45. Mullasseril, P. et al. (2010) Nat. Commun. 1, 90. Mullasseril, P. et al. (2010) Nat. Commun. 1, 90.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300088-1	C-275_10 mg	10 mg	$117		Add to Cart
BHB21300088-2	C-275_100 mg	100 mg	$611		Add to Cart
BHB21300088-3	C-275_25 mg	25 mg	$235		Add to Cart
BHB21300088-4	C-275_5 mg	5 mg	$85		Add to Cart
BHB21300088-5	C-275_50 mg	50 mg	$383		Add to Cart

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