JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

CP 465022 hydrochloride

SKU : BHB21300096

A Selective, Non-Competitive Antagonist of AMPA Receptors and a Modulator of NaV1.6 Channels

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	C-335, C-335_10 mg, C-335_25 mg, C-335_5 mg, C-335_50 mg
Description	CP 465022 hydrochloride (#C-335) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C26H25Cl2FN4O.
Background	CP 465022 hydrochloride is a selective, non-competitive antagonist of the AMPA receptor and a modulator of the voltage-gated sodium NaV1.6 channel. It has an IC50 value of 25 nM for AMPA mediated currents in rat cortical neurons and in human neuronal hNT cell lines, an IC50 of 15 nM can be observed. The inhibitory effect of CP develops slowly. The reversal of its inhibition is also slow upon compound washout, suggesting a slow rate of interaction between CP and the AMPA receptor. This may also be attributed to CP's high lypophilicity and protein binding. CP reduces the efficacy of kainate activation of AMPA receptors at any kainate concentration, indicating that it binds to a site other than the agonist site. Inhibition of the AMPA receptor by CP is neither use-dependent nor voltage-dependent1,2. CP significantly inhibits the persistent inward Na+ current of the NaV1.6 channel in a dose-dependent manner3. This requires caution when ascribing actions to the AMPA receptor based on CP.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	25 nM - 25 uM.
Reconstitution	>25 mM in DMSO. Centrifuge all product preparations before use.
Cas Number	199655-36-2
Molecular Weight	499.4
Solubility	>25 mM in DMSO. Centrifuge all product preparations before use.
Target	AMPA receptors, NaV1.6 Na+ channels
Source	Synthetic
Activity	CP 465022 is a selective, non-competitive AMPA receptor antagonist. It inhibits AMPA receptor-mediated currents in rat cortical neurons (IC50 25 nM)1. It also partially blocks the persistent components of NaV1.6 channel activity2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 3-(2-chlorophenyl)-2-((E)-2-(6-(diethylaminomethyl)pyridin-2-yl)ethenyl)-6-fluoroquinazolin-4-one;hydrochloride.

Purity	>97% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Zhang, W. et al. (2006) Biophys. J. 91, 1336. Lazaro, J.T. et al. (2002) Neuropharmacology 42, 143. Welch, N.C. et al. (2008) Neuropharmacology 55, 1165. Lazaro, J.T. et al. (2002) Neuropharmacology 42, 143. Welch, N.C. et al. (2008) Neuropharmacology 55, 1165.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300096-1	C-335_10 mg	10 mg	$184		Add to Cart
BHB21300096-2	C-335_25 mg	25 mg	$425		Add to Cart
BHB21300096-3	C-335_5 mg	5 mg	$134		Add to Cart
BHB21300096-4	C-335_50 mg	50 mg	$723		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.