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Home / Biochemicals / Small Molecules

CX 546

SKU : BHB21300081

An Agonist of AMPA Receptors

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Mfr.No.	C-210, C-210_10 mg, C-210_100 mg, C-210_25 mg, C-210_5 mg, C-210_50 mg
Description	CX 546 (#C-210) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C14H17NO3.
Background	The AMPAkine families of drugs are positive allosteric modulators of AMPA receptors in the mammalian brain. These compounds facilitate learning and memory in both humans and animals. Positive modulation of AMPA receptors by AMPAkines can improve channel function by increasing receptor sensitivity to endogenous ligands and specific agonists1.The AMPAkine 1-(quinoxalin-6-ylcarbonyl)-piperidine (CX546) is a brain-penetrating compound, which facilitates AMPA receptor-mediated transmission. CX546 has an EC50 in a hippocampal slice preparation of 150 uM as measured by patch clamp in cultured hippocampal neurons. The action of CX546 on AMPA receptor transmission results in memory enhancement, which has been demonstrated in rodents, primates, and humans2.Recent findings now indicate that CX546-mediated AMPA receptor enhancement strengthens neuronal survival signaling, leading to concomitant reduction in hippocampal damage3.CX546 was researched as a treatment for Alzheimer's disease under the brand name Ampalex.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10-630 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	215923-54-9
Molecular Weight	247.3
Solubility	126 mM in DMSO; 100 mM in ethanol. Centrifuge all product preparations before use (10000 x g for 1 min).
Target	AMPA receptors
Source	Synthetic
Activity	CX 546 is a selective AMPA receptor agonist1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2,3-dihydro-1,4-benzodioxin-6-yl)-1-piperidinylmethanone.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Arai, A. and Lynch, G. (1998) Brain Res. 799, 235. Arai, A.C. and Kessler, M. (2007) Curr. Drug Targets 8, 583. Nagarajan, N. et al. (2001) Neuropharmacology 41, 650. Nagarajan, N. et al. (2001) Neuropharmacology 41, 650.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300081-1	C-210_10 mg	10 mg	$117		Add to Cart
BHB21300081-2	C-210_100 mg	100 mg	$849		Add to Cart
BHB21300081-3	C-210_25 mg	25 mg	$263		Add to Cart
BHB21300081-4	C-210_5 mg	5 mg	$85		Add to Cart
BHB21300081-5	C-210_50 mg	50 mg	$476		Add to Cart

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