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Home / Biochemicals / Small Molecules

Cyclopiazonic Acid

SKU : BHB21300106

A Potent Inhibitor of Intracellular Ca2+-ATPase Pump

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Mfr.No.	C-750, C-750_10 mg, C-750_25 mg, C-750_5 mg, C-750_50 mg
Description	Cyclopiazonic Acid (#C-750) is a highly pure, natural, and biologically active compound.
Molecular Formula	C20H20N2O3.
Synonyms	Natural
Background	Cyclopiazonic acid (CPA) is a toxic fungal secondary metabolite. Chemically, it is an indole tetrameric acid. CPA was originally isolated from Penicillium cyclopium and subsequently from other P. cyclopium, Penicillium griseofulvum, Penicillium camembertii, Aspergillus flavus and Aspergillus versicolor.CPA is a highly potent, selective and reversible inhibitor of the sarcoplasmic reticulum (ER) Ca2+-ATPase pump (SERCA). This Ca2+ pump is an integral membrane protein of 994 amino acids that consists of three cytoplasmic domains containing the ATP binding site and ten transmembrane helices containing the two Ca2+ binding sites.1,2The interchange of Ca2+ between the cell cytosol and the ER lumen by SERCA is a central process in intracellular signaling. Moreover, this process has a critical role in the muscle contraction-relaxation cycle, in which the recovery phase relies on transport of calcium into the ER by the action of the SERCA. Inhibition of this pump leads to the decrease of Ca2+ uptake from the cytosol to the ER lumen, thereby causing the depletion of Ca2+ store-operated and increase of cytosolic Ca2+.3-4CPA inhibits the Ca2+ pump by blocking the Ca2+ access channel and immobilizing a subset of transmembrane helices.5
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-10 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	18172-33-3
Molecular Weight	336.4
Solubility	DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	SERCA pump
Activity	Cyclopiazonic acid is a cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca2+-ATPase1,2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (6aR,11aS,11bR)-rel-10-Acetyl-2,6,6a,7,11a,11b,hexahydro-7,7-dimethyl-9H-pyrrolo(1',2':2,3)isoindolo(4,5,6-cd) indol-9-one.

Purity	>99% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to one week at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Suzuki, M. et al. (1992 ) Br. J. Pharmacol. 107, 134. Demaurex, N. et al. (1992) J. Biol. Chem. 267, 2318. Zhang, P. et al. (1998) Nature 392, 835. Xu, C. et al. (2002) J. Mol. Biol. 316, 201. Moncoq, K. et al. (2007) J. Biol. Chem. 282, 9748. Suzuki, M. et al. (1992 ) Br. J. Pharmacol. 107, 134. Demaurex, N. et al. (1992) J. Biol. Chem. 267, 2318.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300106-1	C-750_10 mg	10 mg	$335		Add to Cart
BHB21300106-2	C-750_25 mg	25 mg	$670		Add to Cart
BHB21300106-3	C-750_5 mg	5 mg	$210		Add to Cart
BHB21300106-4	C-750_50 mg	50 mg	$1201		Add to Cart

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