JavaScript is currently not supported/disabled by this browser. Please enable JavaScript for full functionality.

Call Us 1 - 866 - 986 - 9598
[email protected]

Sign Up

Login
- My Order
- Return Requests
- Track my Order

Home / Biochemicals / Small Molecules

CyPPA

SKU : BHB21300070

A Selective and Potent Activator of KCa2.2 and KCa2.3 Channels and a Blocker of TRPM7 Channels

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Request More Infos

Alomone Labs

view supplier details

Order Now

Credit card payments now incur a 3% fee.

Contact us to order

Tel

+1 866.986.9598

Email

[email protected]

Get a Quote

Ask Merchant

Request More Infos

Sample Request

Mfr.No.	C-110, C-110_10 mg, C-110_25 mg, C-110_5 mg, C-110_50 mg
Description	CyPPA (#C-110) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C16H23N5.
Background	Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).Small-conductance Ca2+-activated K+ channels (SK channels) underlie the medium duration after hyperpolarization that follows single or trains of action potentials in many types of neurons. This family is composed of KCa2.1 (SK1), -2.2 (SK2), and -2.3 (SK3) isoforms, which are expressed differentially within the central nervous system (CNS)1,2.CyPPA is an activator of small conductance KCa channels that displays selectivity for SK2 and SK3 channels (EC50 values are 5.6 and 14 uM for SK3 and SK2 respectively and efficacy is 90% and 71% for hSK3 and hSK2, respectively)3. CyPPA displays no activity at SK1 and IK (KCa3.1) channels3.CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels from one another. Therefore, it enriches the repertoire of tools available to test the hypothesis that SK channels may be targets for future CNS drugs4.CyPPA was found to block TRPM7 channels, demonstrating an overlap between pharmacological compounds acting on TRP and KCa channels5.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 uM.
Reconstitution	DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	73029-73-9
Molecular Weight	285.4
Solubility	DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
Target	KCa2.2, KCa2.3, TRPM7 channels
Source	Synthetic
Activity	CyPPA is an activator of small conductance Ca2+-activated K+ channels KCa2.2 (SK2) and KCa2.3 (SK3) with EC50 values of 5.6 and 14 uM for SK3 and SK2 respectively. It displays no activity at SK1 and intermediate conductance KCa (IK) channels1. CyPPA blocks TRPM7 channels2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: N-Cyclohexyl-N-(2-(3,5-dimethyl-pyrazol-1-yl)-6-methyl-4-pyrimidinamine.

Purity	>98%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Kohler, M. et al. (1996) Science 273, 1709. Stocker, M. et al. (2000) Mol Cell Neurosci. 15, 476. Hougaard, C. et al. (2007) Br J. Pharmacol. 151, 655. Seutin, V. et al. (2007) Br J. Pharmacol. 151, 568. Chubanov, V. et al. (2012) Br. J. Pharmacol. 166, 1357. Hougaard, C. et al. (2007) Br J. Pharmacol. 151, 655. Chubanov, V. et al. (2012) Br. J. Pharmacol. 166, 1357.

Have you used this product?

Rate it now..!!

Login to Review

Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300070-1	C-110_10 mg	10 mg	$129		Add to Cart
BHB21300070-2	C-110_25 mg	25 mg	$261		Add to Cart
BHB21300070-3	C-110_5 mg	5 mg	$91		Add to Cart
BHB21300070-4	C-110_50 mg	50 mg	$448		Add to Cart

ebiohippo.com provides biomedical researchers with a one-stop informatic shopping experience by transforming biotechnology products’ data into a ready-to-analyze state. We collect and unify suppliers’ data on a single platform to reduce the time of searching, uncertainty, and cost of scientific experiments.

© 2025 Biohippo. All rights reserved.