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Home / Biochemicals / Small Molecules

Cytochalasin E

SKU : BHB21300105

An Anticancer Compound and a Protein Synthesis and Transport Inhibitor

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Mfr.No.	C-550, C-550_1 mg
Description	Cytochalasin E (#C-550) is a highly pure, natural, and biologically active compound.
Molecular Formula	C28H33NO7.
Background	Cytochalasins are a group of fungal toxin metabolites which bind to actin and alter its polymerization. Cytochalasins bind to the barbed end of the actin filament and prevent both the association and dissociation of actin subunits by inhibiting cell microtubule formation, cell division and cell migration.1-4Cytochalasin E induced a rapid and sustained elevation of intracellular free Ca2+ in B lymphocytes by increasing the extracellular Ca2+ influx.5,6
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 uM.
Reconstitution	Water, DMSO, ethanol, methanol, acetone. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	36011-19-5
Molecular Weight	495.6
Solubility	Water, DMSO, ethanol, methanol, acetone. Centrifuge all product preparations before use (10000 x g 5 min).
Source	Natural
Activity	Cytochalasin E is a fungal toxin which inhibits actin polymerization and blocks the formation of microtubules by inhibiting cell division and cell migration1-4.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 21,23-Dioxa(13)cytochalasa-13,19-diene-1,17,22- trione,6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-,(7S,13E,16S,18R,19E)-.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to two weeks at 4°C or six months at -20°C.Protect from light.

Product Manual	SDS

Reference	Smith, G.F. et al. (1967) Nature 216, 1134. Tellam, R. and Frieden, C. (1982) Biochemistry 21, 3207. Yahara, I. et al. (1982) J. Cell Biol. 92, 69. Matsuyama, T. et al. (1991) J. Immunol. 146, 3736. McDonald, T.P. et al. (1995) J. Biol. Chem. 270, 30359. Baeker, T.R. et al. (1987) J. Immunol. 138, 2691. Smith, G.F. et al. (1967) Nature 216, 1134. Tellam, R. and Frieden, C. (1982) Biochemistry 21, 3207. Yahara, I. et al. (1982) J. Cell. Biol. 92, 69. Matsuyama, T. et al. (1991) J. Immunol. 146, 3736.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300105-1	C-550_1 mg	1 mg	$188		Add to Cart
BHB21300105-2	C-550_1 mg	5x1 mg	$737		Add to Cart

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