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Home / Biochemicals / Small Molecules

DL-AP5

SKU : BHB21300116

A Competitive NMDA Receptor Antagonist

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Mfr.No.	D-140, D-140_10 mg, D-140_100 mg, D-140_25 mg, D-140_5 mg, D-140_50 mg
Description	DL-AP5 (#D-140) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C5H12NO5P.
Synonyms	Synthetic
Background	DL-2-Amino-5-phosphonovaleric acid (DL-AP5) is a selective NMDA receptor antagonist that competitively inhibits the glutamate binding site of NMDA receptors and blocks excitatory synaptic transmission.The NMDA receptor plays important physiological and pathological roles in the central nervous system. The receptor binds the neurotransmitter L-glutamate, and meditates the majority of the fast excitatory neurotransmission in the mammalian brain. In addition, it induces current formation in neurons1.Peripheral administration of AP5 does not cross the blood-brain-barrier and this compound may have an effect on information processing and transmission as well as plasticity2,3.Blockade of NMDARs by AP5 has the ability to trigger synaptic potentiation in the mature hippocampus3.Evidence shows that the inhibitory effects of AP5 are independent of membrane potential but decrease with increasing stimulation frequency3.Several studies have suggested that chronic treatment of the optic tectum with DL-AP5 desegregates eye-specific stripes in three-eyed frogs4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	100 nM - 100 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in sterile water at a concentration of at least 0.1 mg/mL. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. It is recommended to prepare fresh solutions in working buffers just before use. For long-term storage of diluted solutions, we recommend adding 0.1% BSA. Repeat freeze-thawing may result in loss of activity.
Cas Number	76326-31-3
Molecular Weight	197.1
Solubility	50 mg/ml in NaOH (1 M), 5 mg/ml in H2O. Centrifuge all product preparations before use (10000 x g 5 min).
Target	NMDA receptors
Activity	DL-AP5 is an NMDA receptor antagonist. IC50 = 0.28 uM (NR2A), 0.46 uM (NR2B), 1.6 uM (NR2C)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Cited Application: Electrophysiology Chemical Name: 2-amino-5-phosphonopentanoic acid.

Purity	>95%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Nosyreva, E. et al. (2014) Front Mol. Neurosci. 7, 94. Warburton, E.C. et al. (2013) Neuropharmacology 74, 41. Ambert, N. et al. (2010) Open Access Bioinformatics 2, 113. Debski, E.A. et al. (1991) J. Neurosci. 11, 2947. Feuerbach, D. et al. (2010) Eur. J. Pharmacol. 637, 46.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300116-1	D-140_10 mg	10 mg	$76		Add to Cart
BHB21300116-2	D-140_100 mg	100 mg	$375		Add to Cart
BHB21300116-3	D-140_25 mg	25 mg	$163		Add to Cart
BHB21300116-4	D-140_5 mg	5 mg	$46		Add to Cart
BHB21300116-5	D-140_50 mg	50 mg	$249		Add to Cart

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