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Home / Biochemicals / Small Molecules

DM-PPP

SKU : BHB21300125

A Selective Antagonist of mGluR1 Receptors

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Alomone Labs

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Mfr.No.	D-255, D-255_10 mg, D-255_25 mg, D-255_5 mg, D-255_50 mg
Description	DM-PPP (#D-255) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H27NO4.
Pubchem Cid	44431042
Synonyms	Synthetic
Background	DM-PPP is a synthetic compound that acts as a selective and non-competitive antagonist of mGluR1 receptors with an IC50 value of 15.8 nM1. The compound interacts with the 7 transmembrane (7TM) domain of the receptor. In several animal models DM-PPP shows antinociceptive properties1.Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCR) that play an important role in synaptic plasticity and other neuro-physiological and pathological processes including a major role in central sensitization and neuropathic pain. Type 1 mGluRs are mainly expressed on post-synaptic neurons and are known to affect the fate of neuronal progenitor cells and neural stem cell and the formation of the hippocampus2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1 nM - 1 uM.
Reconstitution	Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Molecular Weight	309.19
Solubility	Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	mGluR1
Activity	DM-PPP is a selective and non-competitive antagonist of mGluR1 receptors. It inhibits the receptor in CHO cells with an IC50 of 15.8 nM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-O-((2S)-3,3-dimethylbutan-2-yl) 2-O-propyl 3,5-dimethyl-1H-pyrrole-2,4-dicarboxylate.

Purity	>97%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: Store the reconstituted solution at -20°C for the shortest time possible. Avoid multiple freeze-thaw cycles. We do not recommend storing the product in working solutions for longer than a day. Avoid exposure to light. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Avoid exposure to light. Storage of solutions: -20°C.

Product Manual	SDS

Reference	Micheli, F. et al. (2003) Bioorg. Med. Chem. 11, 171. Eom, H.S. et al. (2016) PLoS One 11, e0147538.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300125-1	D-255_10 mg	10 mg	$235		Add to Cart
BHB21300125-2	D-255_25 mg	25 mg	$468		Add to Cart
BHB21300125-3	D-255_5 mg	5 mg	$168		Add to Cart
BHB21300125-4	D-255_50 mg	50 mg	$843		Add to Cart

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