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Home / Biochemicals / Small Molecules

DNQX

SKU : BHB21300115

AMPA/Kainate Receptor Antagonist

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Alomone Labs

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Mfr.No.	D-131, D-131_10 mg, D-131_100 mg, D-131_25 mg, D-131_250 mg, D-131_50 mg
Description	DNQX (#D-131) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C8H4N4O6.
Background	The first widely used competitive AMPA receptor antagonists were quinoxalinediones (CNQX, DNQX, NBQX), which were highly selective over NMDA receptors but antagonized kainate receptors. Surprisingly, association of AMPA receptors with TARP auxiliary subunits converts DNQX from an antagonist to a weak partial agonist. DNQX induces partial domain closure, consistent with the activity of a partial agonist. DNQX interacts with residues primarily within domain D1 of the clamshell, thereby depriving the agonist of its initial contact sites with the open cleft of the binding pocket1.The concentrations that inhibit 50% of AMPA binding (IC50) for DNQX is 0.50 ± 0.10 uM, and about one-fifth as effective at kainate binding sites, 2.0 ± 0.1 uM in rat cortical membranes2. The IC50 of DNQX is 1 uM in a crystal structure of the GluR2 ligand binding core3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.25-500 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	2379-57-9
Molecular Weight	252.1
Solubility	Up to 40 mM in DMSO. Centrifuge before use (10000 x g, 5 min).
Target	AMPA/kainate receptors
Source	Synthetic
Activity	AMPA/kinate receptor antagonists. Association of AMPA receptors with TARPs converts DNQX from antagonist to weak partial agonist1. The concentration that inhibits 50% of AMPA binding (IC50) for DNQX is 0.50 ± 0.10 uM, and is about one-fifth as effective at kainate binding sites, 2.0 ± 0.1 uM in rat cortical membranes2. The IC50 of DNQX is 1 uM in a crystal structure of the GluR2 ligand binding core3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 6,7-Dinitroquinoxaline-2,3-dione.

Purity	>99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405. Honore, T. et al. (1988) Science 241, 701. Armstrong, N. and Gouaux, E. (2000) Neuron 28, 165. Traynelis, S.F. et al. (2010) Pharmacol. Rev. 62, 405. Honore, T. et al. (1988) Science 241, 701. Armstrong, N. and Gouaux, E. (2000) Neuron 28, 165.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300115-1	D-131_10 mg	10 mg	$37		Add to Cart
BHB21300115-2	D-131_100 mg	100 mg	$137		Add to Cart
BHB21300115-3	D-131_25 mg	25 mg	$57		Add to Cart
BHB21300115-4	D-131_250 mg	250 mg	$266		Add to Cart
BHB21300115-5	D-131_50 mg	50 mg	$88		Add to Cart

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