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Home / Biochemicals / Small Molecules

EMD 66684

SKU : BHB21300131

An Antagonist of Angiotensin II Receptor Type-1

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Mfr.No.	E-160, E-160_10 mg, E-160_25 mg, E-160_5 mg, E-160_50 mg
Description	EMD 66684 (#E-160) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C28H30N8O2HCl.
Background	Angiotensin II is responsible for vasoconstriction in the renin-angiotensin system. In addition to its direct effect on blood vessels it stimulates the synthesis and release of aldosterone and also promotes renal tubular reabsorption of sodium, resulting in water retention1.EMD 66684 is a synthetic antagonist of the Angiotensin II type 1 receptor. It has an effective concentration of 1-100 nM. EMD 66684 completely attenuates Ang II-induced increases in basal and nerve stimulated neuropeptide Y (NPY) overflow from mesenteric arterial beds in a model of spontaneously hypertensive rats. In the same model EMD 66684 also attenuated the effect of Ang II on perfusion pressure2.The antagonistic properties of EMD are also demonstrated in an experiment examining the relation between lipid rafts and angiotensin II receptors. EMD reduces Ang II-induced proliferation of neonatal pig glomerular mesangial cells. EMD also inhibits Ang II-mediated Ca2+ currents and the signal pathway initiated by calcium/calmodulin dependent protein kinases (CAMK) in the same cells3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 nM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	187683-79-0
Molecular Weight	547.05
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	AT1R receptors
Source	Synthetic
Activity	EMD 66684 is an Angiotensin II Type 1 Receptor Antagonist1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 2-(2-butyl-4-oxo-3-((4-(2-(2H-tetrazol-5-yl)phenyl)phenyl)methyl)imidazo(4,5-c)pyridin-5-yl)-N,N-dimethylacetamide;hydrochloride.

Purity	>98%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage before Reconstitution: The product is shipped as a lyophilized powder at room temperature. Upon receipt, store the product at -20°C. Protect from moisture. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Kurtz, T.W. et al. (2012) Vasc. Health Risk Manag. 8, 133. Byku, M. et al. (2008) Am. J. Physiol. Heart. Circ. Physiol. 295, H2188. Adebiyi, A. et al. (2014) Exp. Cell. Res. 324, 92. Mederski, W.W. et al. (1994) J. Med. Chem. 37, 1632.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300131-1	E-160_10 mg	10 mg	$202		Add to Cart
BHB21300131-2	E-160_25 mg	25 mg	$451		Add to Cart
BHB21300131-3	E-160_5 mg	5 mg	$117		Add to Cart
BHB21300131-4	E-160_50 mg	50 mg	$808		Add to Cart

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