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Home / Biochemicals / Small Molecules

FPL 64176

SKU : BHB21300137

An Opener of L-type Ca2+ Channels

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Alomone Labs

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Mfr.No.	F-160, F-160_10 mg, F-160_100 mg, F-160_25 mg, F-160_5 mg, F-160_50 mg
Description	FPL 64176 (#F-160) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C22H21NO3.
Background	FPL 64176 acts as a non-dihydropyridine L-type calcium channel activator with high efficacy properties. It's a benzoylpyrrole compound that has the ability to increase macroscopic inward current through L-type calcium channels. It extends the opening of single calcium channels during depolarization and slows channel closing upon repolarization without affecting currents through other calcium channels1-3.FPL 64176 is being used as a tool for studying the physiological roles and disorders of L-type channels, identification of L-type currents within the mix of channel subtypes and for increasing the contractility of smooth and cardiac muscle2.The use of FPL 64176 has revealed an inactivation and adaptation process for ryanodine receptors and the presence of cardiac sparklets3,4.L-type voltage-gated calcium channels are one of the three major classes (CaV1-CaV3) of voltage-gated calcium channels. They are expressed in many excitable tissues and play as important transducers in the plasma membrane, altering membrane depolarization to intracellular signaling. Many physiological functions, including brain, endocrine, and sensory functions and muscle contraction rely on proper L-type channel activity5.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 nM - 1 uM.
Reconstitution	100 mM in DMSO. Centrifuge all product preparations before use (10 000 x g for 1 min).
Cas Number	120934-96-5
Molecular Weight	347.4
Solubility	100 mM in DMSO. Centrifuge all product preparations before use (10 000 x g for 1 min).
Target	L-type Ca2+ channels
Source	Synthetic
Activity	FPL 64176 is an L-type Ca2+ channel activator, which induces contraction in rat tail artery1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: methyl 4-(2-benzylbenzoyl)-2,5-dimethyl-1H-pyrrole-3-carboxylate.

Purity	>99% (HPLC)
Form	Lyophilized powder.
Storage	Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Zheng, W. et al. (1991) Mol. Pharmacol. 40, 734. Ghais, N.S. et al. (2009) Exp. Physiol. 94, 240. McDonough, S.I. et al. (2005) Biophys. J. 88, 211. Fan, J.S. et al. (2002) Br. J. Pharmacol. 135, 1495. Catterall, W.A. et al. (2003) Pharmacol. Rev. 55, 579. Zheng, W. et al. (1991) Mol. Pharmacol. 40, 734.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300137-1	F-160_10 mg	10 mg	$117		Add to Cart
BHB21300137-2	F-160_100 mg	100 mg	$849		Add to Cart
BHB21300137-3	F-160_25 mg	25 mg	$263		Add to Cart
BHB21300137-4	F-160_5 mg	5 mg	$85		Add to Cart
BHB21300137-5	F-160_50 mg	50 mg	$476		Add to Cart

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