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Home / Biochemicals / Small Molecules

FPTQ

SKU : BHB21300140

A Potent and Selective Antagonist of mGluR1 Receptors

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Alomone Labs

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Mfr.No.	F-185, F-185_10 mg, F-185_25 mg, F-185_5 mg, F-185_50 mg
Description	FPTQ (#F-185) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C17H12FN5.
Background	FPTQ is a synthetic compound that acts as a potent and selective allosteric antagonist of mGluR1 receptors. The compound shows very little inhibition of mGluR5 receptors. FPTQ shows high specific binding with mGluR1 receptor in the rat brain and displays IC50 values of 3.6 nM for human mGluR1 expressed in CHO cells1,2.Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCR) and play an important role in synaptic plasticity and other neuro-physiological and pathological processes including a major role in central sensitization and neuropathic pain. Type 1 mGluRs are mainly found in somatodendritic domains and postsynaptically regulate neuronal excitability and synaptic transmission through several intracellular second messenger systems3,4.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	10 nM - 10 uM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	864863-72-9
Molecular Weight	305.3
Solubility	Up to 50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	mGluR1
Source	Synthetic
Activity	FPTQ is a selective allosteric antagonist of the mGluR1 receptors, inhibiting (3H)FTIDC binding with Ki of 14 nM, and inhibiting L-glutamate evoked Ca2+ mobilization with IC50 of 3.6 nM in CHO cells expressing human mGluR11. It specifically binds mGluR1 in the rat brain2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 6-(1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl)quinolone.

Purity	>97%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C.

Product Manual	SDS

Reference	Suzuki, G. et al. (2009) J. Pharmacol. Sci. 110, 315. Fujinaga, M. et al. (2011) Bioorg. Med. Chem. 19, 102. Satow, A. et al. (2008) J. Pharmacol. Exp. Ther. 326, 577. Eom, H.S. et al. (2016) PLoS One 11, e0147538. Suzuki, G. et al. (2009) J. Pharmacol. Sci. 110, 315. Fujinaga, M. et al. (2011) Bioorg. Med. Chem. 19, 102.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300140-1	F-185_10 mg	10 mg	$235		Add to Cart
BHB21300140-2	F-185_25 mg	25 mg	$468		Add to Cart
BHB21300140-3	F-185_5 mg	5 mg	$168		Add to Cart
BHB21300140-4	F-185_50 mg	50 mg	$843		Add to Cart

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