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Home / Biochemicals / Small Molecules

Frescolat MGA

SKU : BHB21300138

An Activator of TRPM8 Channels

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Alomone Labs

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Mfr.No.	F-165, F-165_1 g, F-165_10 g, F-165_5 g
Description	Frescolat MGA (#F-165) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C13H24O3.
Synonyms	Synthetic
Background	Frescolat MGA is a synthetic compound that acts as a TRPM8 channel activator. Studies show that Frescolat MGA has the ability to activate mouse TRPM8 channels and to produce concentration-dependent increase in Ca2+ levels with an EC50 value of 4.8 uM1.TRPM8 channel is a member of the TRP channels superfamily. TRPM8 is Ca2+-permeable, nonselective cation channel that is activated by temperatures in the range of 8-28°C and by chemical agonists such as menthol and icilin. TRPM8 is specifically expressed in temperature-sensing trigeminal and dorsal root ganglion neurons and is up-regulated in prostate cancer and other malignancies1,2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-10 uM.
Reconstitution	Up to 200 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Cas Number	63187-91-7
Molecular Weight	228.33
Solubility	Up to 200 mM in DMSO. Centrifuge all products before use (10000 x g 5 min).
Target	TRPM8 channel
Activity	Frescolat MGA is a TRPM8 channel activator and cooling agent. It activates mouse TRPM8 channels with EC50 of 4.8 uM1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (9-methyl-6-propan-2-yl-1,4-dioxaspiro(4.5)decan-3-yl)methanol.

Purity	>97%
Form	Colorless Liquid
Storage	Storage of solutions: Up to three months at -20°C.

Product Manual	SDS

Reference	Tsumura, M. et al. (2013) PLoS One 8, e82233. Behrendt, H.J. et al. (2004) Br. J. Pharmacol. 141, 737. Behrendt, H.J. et al. (2004) Br. J. Pharmacol. 141, 737.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300138-1	F-165_1 g	1 g	$66		Add to Cart
BHB21300138-2	F-165_10 g	10 g	$117		Add to Cart
BHB21300138-3	F-165_5 g	5 g	$85		Add to Cart

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