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Home / Biochemicals / Small Molecules

FTIDC

SKU : BHB21300141

A Potent and Selective Antagonist of mGluR1 Receptors

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Mfr.No.	F-190, F-190_10 mg, F-190_25 mg, F-190_5 mg, F-190_50 mg
Description	FTIDC (#F-190) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C18H23FN6O.
Background	FTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibition of FTIDC for mGluR1 receptors is shown to be in noncompetitive manner and displays IC50 values of 5.8 and 3.1 nM for human and mouse mGluR1 expressed in CHO cells respectively1.Studies using chimeric and mutant mGluR1 show that transmembrane (TM) domains 4 to 7, play an important role in the antagonistic properties of FTIDC. The compound has oral activity on recombinant human, mouse, and rat mGluR1 without species differences in its antagonistic activity. The compound is considered to be a valuable tool for elucidating the functions of mGluR1 in rodents and in humans1,2.Metabotropic glutamate receptors (mGluRs) are G-protein coupled receptors (GPCR) and play an important role in synaptic plasticity and other neuro-physiological and pathological processes including a major role in central sensitization and neuropathic pain. Type 1 mGluRs are mainly found in somatodendritic domains and postsynaptically regulate neuronal excitability and synaptic transmission through several intracellular second messenger systems2,3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	1-100 nM.
Reconstitution	Centrifuge the vial before adding solvent (10,000 x g for 5 minutes) to spin down all the powder to the bottom of the vial. The lyophilized product may be difficult to visualize. Add solvent directly to the centrifuged vial. Tap the vial to aid in dissolving the lyophilized product. Tilt and gently roll the liquid over the walls of the vial. Avoid vigorous vortexing. Light vortexing for up to 3 seconds is acceptable if needed. The product is soluble in pure water at high micromolar concentrations (100 uM - 1 mM). For long-term storage in solution, we recommend preparing a stock solution by dissolving the product in double-distilled water (ddH2O) at a concentration between 100-1000x of the final working concentration. Divide the stock solution into small aliquots and store at -20°C. Before use, thaw the relevant vial(s) and dilute to the desired working concentration in your working buffer. Centrifuge all product preparations before use. It is recommended to prepare fresh solutions in working buffers just before use. Avoid multiple freeze-thaw cycles to maintain biological activity
Cas Number	873551-53-2
Molecular Weight	358.4
Solubility	Up to 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	mGluR1
Source	Synthetic
Activity	FTIDC is a potent and selective allosteric antagonist of the mGluR1 receptor, shown to inhibit L-glutamate-induced Ca2+ mobilization in human and mouse mGluR1a-expressing CHO cells (IC50 values of 5.8 nM and 3.1 nM, respectively), while having a 1000-fold weaker activity against human and rat mGluR5 (IC50 values of 6.2 uM and 9.9 uM, respectively)1.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 4-(1-(2-fluoropyridin-3-yl)-5-methyltriazol-4-yl)-N-methyl-N-propan-2-yl-3,6-dihydro-2H-pyridine-1-carboxamide.

Purity	>97% (HPLC)
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C.

Product Manual	SDS

Reference	Suzuki, G. et al. (2007) J. Pharmacol. Exp. Ther. 321,1144. Satow, A. et al. (2008) J. Pharmacol. Exp. Ther. 326, 577. Eom, H.S. et al. (2016) PLoS One 11, e0147538. Suzuki, G. et al. (2007) J. Pharmacol. Exp. Ther. 321, 1144.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300141-1	F-190_10 mg	10 mg	$235		Add to Cart
BHB21300141-2	F-190_25 mg	25 mg	$468		Add to Cart
BHB21300141-3	F-190_5 mg	5 mg	$168		Add to Cart
BHB21300141-4	F-190_50 mg	50 mg	$843		Add to Cart

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