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Home / Biochemicals / Small Molecules

Gambogic amide

SKU : BHB21300162

A Selective Agonist of TrkA Receptors

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Alomone Labs

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Mfr.No.	G-235, G-235_1 mg, G-235_10 mg, G-235_2.5 mg, G-235_5 mg
Description	Gambogic amide (#G-235) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C38H45NO7.
Synonyms	Synthetic
Background	Gambogic amide, is a small molecule that mimics nerve growth factor (NGF) and is a selective agonist of TrkA receptor that strongly induces its tyrosine phosphorylation and downstream signaling activation.Gambogic amide interacts with the cytoplasmic juxtamembrane domain of TrkA receptor and triggers its dimerization. It selectively binds, activates and upregulates the expression of TrkA receptors at nanomolar concentrations but not TrkB or TrkC.Gambogic acid is a major active ingredient of gamboge, a resin exuded from the Garcinia hanburyi tree in southeast Asia. Gambogic amide also possesses neurotrophic activity in various neural injury animal models and prevents glutamate-induced neuronal cell death1,2.Gambogic amide shows antiapoptotic activity and demonstrates EC50 value of 5 nM3.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.1-1 uM.
Reconstitution	Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Cas Number	286935-60-2
Molecular Weight	627.78
Solubility	Soluble up to 100 mM in DMSO. Centrifuge all products before handling (10000 x g 5 min).
Target	TrkA receptors
Activity	Gambogic amide, an NGF-mimetic small molecule, is a TrkA receptor agonist, shown to selectively bind, activate and upregulate the expression of TrkA receptors at nanomolar concentrations (Kd = 75 nM). Gambogic amide shows antiapoptotic activity (EC50 = 5 nM), neuroprotective and anti-cancer effects in vitro and in vivo1-3.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: (2Z)-4-((1S,2S,8R,17S,19R)-12-Hydroxy-8,21,21-trimethyl-5-(3-methyl-2-buten-1-yl)-8-(4-methyl-3-penten-1-yl)-14,18-dioxo-3,7,20-trioxahexacyclo(15.4.1.02,15.02,19.04,13.06,11)docosa-4(13),5,9, 11,15-pentaen-19-yl)-2-methyl-2-butenamide.

Purity	>95%
Form	Lyophilized Powder
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: -20°C. It is recommended to aliquot stock solutions to prevent repeated thawing and freezing.

Product Manual	SDS

Reference	Jang, S.W. et al. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 16329. Chan, C.B. et al. (2009) Oncogene 28, 3825. Shen, J. and Yu, Q. (2015) Pharmacol. Rep. 67, 217.

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300162-1	G-235_1 mg	1 mg	$117		Add to Cart
BHB21300162-2	G-235_10 mg	10 mg	$611		Add to Cart
BHB21300162-3	G-235_2.5 mg	2.5 mg	$235		Add to Cart
BHB21300162-4	G-235_5 mg	5 mg	$383		Add to Cart

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