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Home / Biochemicals / Small Molecules

Ganaxolone

SKU : BHB21300148

A Selective Positive Modulator of GABA(A) Receptors

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Mfr.No.	G-120, G-120_10 mg, G-120_25 mg, G-120_5 mg, G-120_50 mg
Description	Ganaxolone (#G-120) is a highly pure, synthetic, and biologically active compound.
Molecular Formula	C22H36O2.
Synonyms	Synthetic
Background	Ganaxolone (CCD 1042) is a 3beta-methyl-substituted synthetic analogue of the endogenous neuroactive steroid allopregnanolone with anticonvulsant, anxiolytic, and sedative effects. The methyl group on the compound makes it more resistant to metabolism and increases the compound's half life by hours.Ganaxolone is a selective, potent and positive allosteric modulator of the GABA(A) receptors. It enhances the binding of the benzodiazepine and the GABA sites. In several clinical studies, ganaxolone treatment showed to have protective activity in several seizures models in adults and in children with history of infantile spasms. In adults the compound successfully reduced the frequency of partial seizures2,3.Ionotropic GABA(A) receptors mediate GABA action, a major inhibitory neurotransmitter, through the central nervous system. The receptors are considered to be a major target of antiseizure drugs1,2.
Shipping	Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C
Concentration	0.01-10 uM.
Reconstitution	50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Cas Number	38398-32-2
Molecular Weight	332.5
Solubility	50 mM in DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
Target	GABA(A) receptors
Activity	Ganaxolone potentiates GABA-evoked chloride currents. In Xenopus oocytes expressing the human GABA(A) receptor subunits alpha2beta1gamma2L, alpha3beta1gamma2L and alpha1beta1gamma2L the respective EC50 values are 94, 122 and 213 nM1. It is also used as an anticonvulsant, antiepileptic drug2.
Country Of Origin	Israel/IL
UNSPSC Code	41116134
Application	FC- Flow cytometry, IFC- Indirect flow cytometry, IHC- Immunohistochemistry,LCI- Live cell imaging, Calcium imaging assay,Cell survival assay, Electrophysiology, Neurite outgrowth assay
Lead Time	1-2 Business Days
Notes	Bioassay Tested: Yes Chemical Name: 1-((3R,5S,8R,9S,10S,13S,14S,17S)-3-hydroxy-3,10,13-trimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta(a)phenanthren-17-yl)ethanone.

Purity	>=99%
Form	Lyophilized powder.
Storage	Storage After Reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods (up to 6 months), small aliquots should be stored at -20°C. We do not recommend storing the product in working solutions for longer than a few days. Avoid multiple freeze-thaw cycles. Storage of solutions: Up to four weeks at 4°C or three months at -20°C.

Product Manual	SDS

Reference	Carter, R.B. et. al. (1997) J. Pharmacol. Exp. Ther. 280, 1284. Nohria, V. and Giller, E. (2007) Neurotherapeutics 4, 102. Reddy, D.S. and Rogawski, M.A. (2010) Epilepsy Res. 89, 254. Carter, R.B. et. al. (1997) J. Pharmacol. Exp. Ther. 280, 1284. 0

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Combination SKU	Supplier No.	Size	Your price	Quantity
BHB21300148-1	G-120_10 mg	10 mg	$168		Add to Cart
BHB21300148-2	G-120_25 mg	25 mg	$375		Add to Cart
BHB21300148-3	G-120_5 mg	5 mg	$117		Add to Cart
BHB21300148-4	G-120_50 mg	50 mg	$595		Add to Cart

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